Synergy between Colistin and the Signal Peptidase Inhibitor MD3 Is Dependent on the Mechanism of Colistin Resistance in Acinetobacter baumannii

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UDC.coleccionInvestigación
UDC.departamentoBioloxía
UDC.departamentoFisioterapia, Medicina e Ciencias Biomédicas
UDC.endPage4379
UDC.institutoCentroCICA - Centro Interdisciplinar de Química e Bioloxía
UDC.institutoCentroINIBIC - Instituto de Investigacións Biomédicas de A Coruña
UDC.issue7 (July)
UDC.journalTitleAntimicrobial Agents and Chemotherapy
UDC.startPage4375
UDC.volume60 (2016)
dc.contributor.authorMartínez Guitián, Marta
dc.contributor.authorVázquez-Ucha, Juan Carlos
dc.contributor.authorOdingo, Joshua
dc.contributor.authorParish, Tanya
dc.contributor.authorPoza, Margarita
dc.contributor.authorWhite, Richard D.
dc.contributor.authorBou, Germán
dc.contributor.authorWareham, David
dc.contributor.authorBeceiro Casas, Alejandro
dc.date.accessioned2026-02-18T21:07:56Z
dc.date.available2026-02-18T21:07:56Z
dc.date.issued2016-06-20
dc.description.abstract[Abstract] Synergy between colistin and the signal peptidase inhibitor MD3 was tested against isogenic mutants and clinical pairs of Acinetobacter baumannii isolates. Checkerboard assays and growth curves showed synergy against both colistin-susceptible strains (fractional inhibitory concentration index [FICindex] = 0.13 to 0.24) and colistin-resistant strains with mutations in pmrB and phosphoethanolamine modification of lipid A (FICindex = 0.14 to 0.25) but not against colistin-resistant Δlpx strains with loss of lipopolysaccharide (FICindex = 0.75 to 1). A colistin/MD3 combination would need to be targeted to strains with specific colistin resistance mechanisms.
dc.description.sponsorshipThis work, including the efforts of German Bou, was funded by MINECO | Instituto de Salud Carlos III (ISCIII) (PI12/00552). This work, including the efforts of Margarita Poza and Alejandro Beceiro, was funded by MINECO | Instituto de Salud Carlos III (ISCIII) (PI14/00059). This work, including the efforts of Juan C. Vázquez-Ucha and Alejandro Beceiro, was funded by MINECO | Instituto de Salud Carlos III (ISCIII) (CP13/00226). This work was supported by the Spanish National Plans for Scientific Research, Development and Technological Innovation 2008-2011 and 2013-2016 and funded by the ISCIII-General Subdirection of Assessment and Promotion of the Research European Regional Development Fund (ERDF) “A way of making Europe” and also by the Spanish Network for Research in Infectious Diseases (REIPI RD12/0015).
dc.identifier.citationMartínez-Guitián M, Vázquez-Ucha JC, Odingo J, Parish T, Poza M, Waite RD, Bou G, Wareham DW, Beceiro A.2016.Synergy between Colistin and the Signal Peptidase Inhibitor MD3 Is Dependent on the Mechanism of Colistin Resistance in Acinetobacter baumannii. Antimicrob Agents Chemother60:.https://doi.org/10.1128/aac.00510-16
dc.identifier.doi10.1128/aac.00510-16
dc.identifier.issn0066-4804
dc.identifier.issn1098-6596
dc.identifier.urihttps://hdl.handle.net/2183/47451
dc.language.isoeng
dc.publisherAmerican Society for Microbiology
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI12%2F00552/ES/Estudios preclínicos con D-aminoácidos para atenuar la virulencia de Acinetobacter baumannii y otros patógenos multirresistentes: Una nueva estrategia para erradicar una infección/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI14%2F00059/ES/Nuevas estrategias frente al patógeno multirresistente Acinetobacter baumannii: silenciamiento (siRNA) bacteriano y nuevos inhibidores químicos. Evaluación en estudios preclínicos/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//CP13%2F00226/ES/CP13%2F00226/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//RD12%2F0015%2F0014/ES/Enfermedades infecciosas/
dc.relation.urihttps://doi.org/10.1128/aac.00510-16
dc.rights© American Society for Microbiology.
dc.rights.accessRightsopen access
dc.titleSynergy between Colistin and the Signal Peptidase Inhibitor MD3 Is Dependent on the Mechanism of Colistin Resistance in Acinetobacter baumannii
dc.typejournal article
dc.type.hasVersionVoR
dspace.entity.typePublication
relation.isAuthorOfPublicationa68d08dc-09ba-453e-8928-7c08e5b14a4b
relation.isAuthorOfPublication909e08d1-6ed1-4b99-9e9e-c64eb72e7dea
relation.isAuthorOfPublication.latestForDiscoverya68d08dc-09ba-453e-8928-7c08e5b14a4b

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