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https://hdl.handle.net/2183/47451

Synergy between Colistin and the Signal Peptidase Inhibitor MD3 Is Dependent on the Mechanism of Colistin Resistance in Acinetobacter baumannii

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URI: https://hdl.handle.net/2183/47451
DOI: 10.1128/aac.00510-16

Publication date

2016-06-20

Authors

Martínez Guitián, Marta
Vázquez-Ucha, Juan Carlos
Odingo, Joshua
Parish, Tanya
White, Richard D.
Wareham, David
Beceiro Casas, Alejandro

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Martínez-Guitián M, Vázquez-Ucha JC, Odingo J, Parish T, Poza M, Waite RD, Bou G, Wareham DW, Beceiro A.2016.Synergy between Colistin and the Signal Peptidase Inhibitor MD3 Is Dependent on the Mechanism of Colistin Resistance in Acinetobacter baumannii. Antimicrob Agents Chemother60:.https://doi.org/10.1128/aac.00510-16

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Abstract

[Abstract] Synergy between colistin and the signal peptidase inhibitor MD3 was tested against isogenic mutants and clinical pairs of Acinetobacter baumannii isolates. Checkerboard assays and growth curves showed synergy against both colistin-susceptible strains (fractional inhibitory concentration index [FICindex] = 0.13 to 0.24) and colistin-resistant strains with mutations in pmrB and phosphoethanolamine modification of lipid A (FICindex = 0.14 to 0.25) but not against colistin-resistant Δlpx strains with loss of lipopolysaccharide (FICindex = 0.75 to 1). A colistin/MD3 combination would need to be targeted to strains with specific colistin resistance mechanisms.

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https://doi.org/10.1128/aac.00510-16

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© American Society for Microbiology.

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