The novel polymyxin analogue SPR206 exhibits higher activity than colistin against both colistin-susceptible and colistin-resistant strains of Acinetobacter baumannii
| UDC.coleccion | Investigación | |
| UDC.departamento | Fisioterapia, Medicina e Ciencias Biomédicas | |
| UDC.grupoInv | Investigación en Microbiología (INIBIC) | |
| UDC.institutoCentro | INIBIC - Instituto de Investigacións Biomédicas de A Coruña | |
| UDC.issue | 7 | |
| UDC.journalTitle | Antimicrobial Agents and Chemotherapy | |
| UDC.startPage | e0194024 | |
| UDC.volume | 69 | |
| dc.contributor.author | Outeda-García, Michelle | |
| dc.contributor.author | García-Pose, Andrea | |
| dc.contributor.author | Guijarro-Sánchez, Paula | |
| dc.contributor.author | Rodríguez-Coello, Arianna | |
| dc.contributor.author | Báez-Barroso, Gabriela Alejandra | |
| dc.contributor.author | Maceiras, Romina | |
| dc.contributor.author | Alonso-García, Isaac | |
| dc.contributor.author | Arca-Suárez, Jorge | |
| dc.contributor.author | Vázquez-Ucha, Juan Carlos | |
| dc.contributor.author | Bou, Germán | |
| dc.contributor.author | Beceiro Casas, Alejandro | |
| dc.date.accessioned | 2025-09-03T06:40:05Z | |
| dc.date.available | 2025-09-03T06:40:05Z | |
| dc.date.issued | 2025-05-20 | |
| dc.description.abstract | [Abstract] Colistin resistance is increasing globally and complicates treatments of A. baumannii infections. The next-generation polymyxin SPR206 shows potent activity against multidrug-resistant Gram-negative pathogens with low toxicity. SPR206 exhibited higher activity against colistin-susceptible and colistin-resistant strains (MIC50/MIC90 = 0.12/0.25 mg/L), and resistance was only detected in 1/118 strains (MIC ≥4 mg/L). Mutations in pmrCAB, linked to colistin resistance, do not seem to confer resistance to the novel polymyxin, which retains a high level of activity. | |
| dc.description.sponsorship | This research was supported by Projects PI20/01212 and PI23/00851 awarded to A.B., Project PI21/00704 awarded to G.B., and Project PI22/01212 awarded to J.A.-S., all funded by Instituto de Salud Carlos III (ISCIII) and co-funded by the European Union. The research was also supported by CIBER-Consorcio Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III (CB21/13/00055), Ministerio de Ciencia e Innovación, and Unión Europea—NextGenerationEU, and by project IN607D 2021/12 awarded to A.B., IN607A 2020/05 to G.B., and IN607D 2024/008 to J.A.-S. (GAIN-Agencia Gallega de Innovación). Consellería de Economía, Emprego e Industria). J.A.-S. was financially supported by the Juan Rodés program (ISCIII, JR21/00026). J.C.V.-U. was financially supported by IN606B-2022/009 (Xunta de Galicia). P.G.-S. was financially supported by IN606A 2021/021 Grant (Xunta de Galicia). M.O.-G. was financially supported by IN606A 2023/023. I.A.-G. was financially supported by the Juan Rodés (ISCIII, JR23/00036). A.B.-B. was financially supported by IN606A-2024/033. | |
| dc.identifier.citation | Outeda-García M, Garcia-Pose A, Guijarro-Sánchez P, Rodríguez-Coello A, Báez-Barroso GA, Maceiras R, Alonso-García I, Arca-Suárez J, Vázquez-Ucha JC, Bou G, Beceiro A; Spanish National Acinetobacter spp. 2020 Study Group. The novel polymyxin analogue SPR206 exhibits higher activity than colistin against both colistin-susceptible and colistin-resistant strains of Acinetobacter baumannii. Antimicrob Agents Chemother. 2025 Jul 2;69(7):e0194024. | |
| dc.identifier.doi | 10.1128/aac.01940-24 | |
| dc.identifier.issn | 0066-4804 | |
| dc.identifier.uri | https://hdl.handle.net/2183/45707 | |
| dc.language.iso | eng | |
| dc.publisher | American Society of Microbiology | |
| dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI20%2F01212/ES/DESARROLLO Y EVALUACION DE NUEVAS MOLECULAS ANTIMICROBIANAS DIRIGIDAS A PATOGENOS MULTIRRESISTENTES (INHIBIDORES DE ß-LACTAMASAS Y CONJUGADOS TETRACICLINAS-SIDEROFOROS). ESTUDIO NACIONAL ACINETOBACTER SPP./ | |
| dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI21%2F00704/ES/VACUNAS AUXOTROFAS ORALES PARA LA ERRADICACION DE BACTERIAS INTESTINALES: COLONIZACIÓN INTESTINAL POR KLEBSIELLA PNEUMONIAE MULTIRRESISTENTE COMO MODELO/ | |
| dc.relation.uri | https://doi.org/10.1128/aac.01940-24 | |
| dc.rights | Attribution 4.0 International | en |
| dc.rights.accessRights | open access | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Acinetobacter baumannii | |
| dc.subject | SPR206 | |
| dc.subject | Antimicrobial resistance | |
| dc.subject | Colistin | |
| dc.title | The novel polymyxin analogue SPR206 exhibits higher activity than colistin against both colistin-susceptible and colistin-resistant strains of Acinetobacter baumannii | |
| dc.type | journal article | |
| dc.type.hasVersion | VoR | |
| dspace.entity.type | Publication | |
| relation.isAuthorOfPublication | 909e08d1-6ed1-4b99-9e9e-c64eb72e7dea | |
| relation.isAuthorOfPublication.latestForDiscovery | 909e08d1-6ed1-4b99-9e9e-c64eb72e7dea |