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https://hdl.handle.net/2183/45707 The novel polymyxin analogue SPR206 exhibits higher activity than colistin against both colistin-susceptible and colistin-resistant strains of Acinetobacter baumannii
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Outeda-García, Michelle
García-Pose, Andrea
Guijarro-Sánchez, Paula
Rodríguez-Coello, Arianna
Báez-Barroso, Gabriela Alejandra
Maceiras, Romina
Alonso-García, Isaac
Arca-Suárez, Jorge
Vázquez-Ucha, Juan Carlos
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Outeda-García M, Garcia-Pose A, Guijarro-Sánchez P, Rodríguez-Coello A, Báez-Barroso GA, Maceiras R, Alonso-García I, Arca-Suárez J, Vázquez-Ucha JC, Bou G, Beceiro A; Spanish National Acinetobacter spp. 2020 Study Group. The novel polymyxin analogue SPR206 exhibits higher activity than colistin against both colistin-susceptible and colistin-resistant strains of Acinetobacter baumannii. Antimicrob Agents Chemother. 2025 Jul 2;69(7):e0194024.
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Abstract
[Abstract] Colistin resistance is increasing globally and complicates treatments of A. baumannii infections. The next-generation polymyxin SPR206 shows potent activity against multidrug-resistant Gram-negative pathogens with low toxicity. SPR206 exhibited higher activity against colistin-susceptible and colistin-resistant strains (MIC50/MIC90 = 0.12/0.25 mg/L), and resistance was only detected in 1/118 strains (MIC ≥4 mg/L). Mutations in pmrCAB, linked to colistin resistance, do not seem to confer resistance to the novel polymyxin, which retains a high level of activity.
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