Differential Characteristics of HMGB2 Versus HMGB1 and their Perspectives in Ovary and Prostate Cancer

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UDC.coleccionInvestigaciónes_ES
UDC.departamentoBioloxíaes_ES
UDC.endPage3289es_ES
UDC.grupoInvRegulación da Expresión Xénica e Aplicacións (EXPRELA)es_ES
UDC.institutoCentroCICA - Centro Interdisciplinar de Química e Bioloxíaes_ES
UDC.issue20es_ES
UDC.journalTitleCurrent Medicinal Chemistryes_ES
UDC.startPage3271es_ES
UDC.volume27 (2020)es_ES
dc.contributor.authorCámara-Quílez, M.
dc.contributor.authorBarreiro-Alonso, Aida
dc.contributor.authorRodríguez-Belmonte, Esther
dc.contributor.authorQuindós-Varela, María
dc.contributor.authorCerdán, María Esperanza
dc.contributor.authorLamas, Mónica
dc.date.accessioned2025-01-15T16:03:49Z
dc.date.available2025-01-15T16:03:49Z
dc.date.issued2020
dc.descriptionThis is an accepted version of the published document. This version of the article has been accepted for publication, after peer review, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The published manuscript is available at EurekaSelect via https://doi.org/10.2174/0929867326666190123120338.es_ES
dc.description.abstract[Abstract] We have summarized common and differential functions of HMGB1 and HMGB2 proteins with reference to pathological processes, with a special focus on cancer. Currently, several “omic” approaches help us compare the relative expression of these 2 proteins in healthy and cancerous human specimens, as well as in a wide range of cancer-derived cell lines, or in fetal versus adult cells. Molecules that interfere with HMGB1 functions, though through different mechanisms, have been extensively tested as therapeutic agents in animal models in recent years, and their effects are summarized. The review concludes with a discussion on the perspectives of HMGB molecules as targets in prostate and ovarian cancers.es_ES
dc.description.sponsorshipThis work has been funded by the Project Nº PI14/01031, integrated into the National Plan for Sci- entific Research, Development and Technological Innovation 2013-2016 of the ISCIII - General Sub- direction of Assessment and Promotion of the Research – European Regional Development Fund (FEDER) “A way of making Europe”. Funding is also acknowledged by Xunta de Galicia (Consolidación Grupos Referencia Competitiva; Contract No. ED431C 2016-012)es_ES
dc.description.sponsorshipXunta de Galicia; ED431C 2016-012es_ES
dc.identifier.citationCámara-Quílez M, Barreiro-Alonso A, Rodríguez-Bemonte E, Quindós-Varela M, Cerdán ME, Lamas-Maceiras M. Differential Characteristics of HMGB2 Versus HMGB1 and their Perspectives in Ovary and Prostate Cancer. Current Medicinal Chemistry. 2020;27(20):3271–89es_ES
dc.identifier.doi10.2174/0929867326666190123120338
dc.identifier.issn1875-533X
dc.identifier.urihttp://hdl.handle.net/2183/40728
dc.language.isoenges_ES
dc.publisherBentham Sciencees_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PI14%2F01031/ES/Interactoma de HMGB1 y HMGB2 y su relación con cáncer de ovario y próstata/es_ES
dc.relation.urihttps://doi.org/10.2174/0929867326666190123120338es_ES
dc.rights.accessRightsopen accesses_ES
dc.subjectProstate canceres_ES
dc.subjectOvarian canceres_ES
dc.subjectDifferential expressiones_ES
dc.subjectHMGB proteinses_ES
dc.subjectDrug targetses_ES
dc.subjectOmic approacheses_ES
dc.titleDifferential Characteristics of HMGB2 Versus HMGB1 and their Perspectives in Ovary and Prostate Canceres_ES
dc.typejournal articlees_ES
dspace.entity.typePublication
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