Differential Characteristics of HMGB2 Versus HMGB1 and their Perspectives in Ovary and Prostate Cancer

Cámara-Quílez, M.; Barreiro-Alonso, Aida; Rodríguez-Belmonte, Esther; Quindós-Varela, María; Cerdán, María Esperanza; Lamas, Mónica

Use this link to cite:

http://hdl.handle.net/2183/40728

Differential Characteristics of HMGB2 Versus HMGB1 and their Perspectives in Ovary and Prostate Cancer

Files

Lamas_Monica_2020_Differential_characteristics_HMGB2_HMGB1.pdf (853.23 KB)

Identifiers

URI: http://hdl.handle.net/2183/40728

DOI: 10.2174/0929867326666190123120338

Publication date

2020

Authors

Cámara-Quílez, M.

Barreiro-Alonso, Aida

Rodríguez-Belmonte, Esther

Quindós-Varela, María

Cerdán, María Esperanza

Lamas, Mónica

Bibliographic citation

Cámara-Quílez M, Barreiro-Alonso A, Rodríguez-Bemonte E, Quindós-Varela M, Cerdán ME, Lamas-Maceiras M. Differential Characteristics of HMGB2 Versus HMGB1 and their Perspectives in Ovary and Prostate Cancer. Current Medicinal Chemistry. 2020;27(20):3271–89

Abstract

[Abstract] We have summarized common and differential functions of HMGB1 and HMGB2 proteins with reference to pathological processes, with a special focus on cancer. Currently, several “omic” approaches help us compare the relative expression of these 2 proteins in healthy and cancerous human specimens, as well as in a wide range of cancer-derived cell lines, or in fetal versus adult cells. Molecules that interfere with HMGB1 functions, though through different mechanisms, have been extensively tested as therapeutic agents in animal models in recent years, and their effects are summarized. The review concludes with a discussion on the perspectives of HMGB molecules as targets in prostate and ovarian cancers.

Description

This is an accepted version of the published document. This version of the article has been accepted for publication, after peer review, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The published manuscript is available at EurekaSelect via https://doi.org/10.2174/0929867326666190123120338.