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Accelerating water exchange in GdIII–DO3A-derivatives by favouring the dissociative mechanism through hydrogen bonding

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URI: http://hdl.handle.net/2183/30064

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2018-12-10

Authors

Leone, Loredana
Milanesio, Marco
Tei, Lorenzo

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L. Leone, D. Esteban-Gómez, C. Platas-Iglesias, M. Milanesio and L. Tei, Accelerating water exchange in Gd III -DO3A-derivatives by favouring the dissociative mechanism through hydrogen bonding, Chem. Commun., 2019, 55, 513–516. DOI: 10.1039/C8CC08556K.

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[Abstract] The GdIII-complexes of DO3A-acetophenone and ortho- or para- hydroxyacetophenone ligands have been investigated to assess the effect of the presence of a phenol group on the relaxivity and on the water exchange rate of these potential MRI contrast agents. H-Bonding between the ortho-phenol(ate) groups and the water molecules involved in the dissociative exchange mechanism is shown to speed up the water exchange rate by stabilizing the eight-coordinate transition state.

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https://doi.org/10.1039/C8CC08556K

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Investigación (FCIE)