Action mechanisms of small extracellular vesicles in inflammaging

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UDC.coleccionInvestigaciónes_ES
UDC.departamentoFisioterapia, Medicina e Ciencias Biomédicases_ES
UDC.grupoInvGrupo de Investigación en Terapia Celular e Medicina Rexenerativa (TCMR)es_ES
UDC.issue4es_ES
UDC.journalTitleLifees_ES
UDC.startPage546es_ES
UDC.volume12es_ES
dc.contributor.authorMato-Basalo, Rocío
dc.contributor.authorLucio-Gallego, Sergio
dc.contributor.authorAlarcón Veleiro, Carmen
dc.contributor.authorSacristán-Santos, Marta
dc.contributor.authorMiranda Quintana, María del Pilar
dc.contributor.authorMorente-López, Miriam
dc.contributor.authorDe-Toro, Javier
dc.contributor.authorSilva-Fernández, Lucía
dc.contributor.authorGonzález Rodríguez, Alba
dc.contributor.authorArufe, M.C.
dc.contributor.authorFafián-Labora, J. A.
dc.date.accessioned2022-05-11T11:53:05Z
dc.date.available2022-05-11T11:53:05Z
dc.date.issued2022-04-06
dc.descriptionThis article belongs to the Special Issue Extracellular Vesicles Research in Inflamm-Aginges_ES
dc.description.abstract[Abstract] The accumulation process of proinflammatory components in the body due to aging influences intercellular communication and is known as inflammaging. This biological mechanism relates the development of inflammation to the aging process. Recently, it has been reported that small extracellular vesicles (sEVs) are mediators in the transmission of paracrine senescence involved in inflammatory aging. For this reason, their components, as well as mechanisms of action of sEVs, are relevant to develop a new therapy called senodrugs (senolytics and senomorphic) that regulates the intercellular communication of inflammaging. In this review, we include the most recent and relevant studies on the role of sEVs in the inflammatory aging process and in age-related diseases such as cancer and type 2 diabetes.es_ES
dc.description.sponsorshipJ.F.L. was funded by Xunta de Galicia, Grant Number ED481D-2021-020. M.C.A. received a grant from the Spanish National Health Institute Carlos III (PI20/00497)
dc.description.sponsorshipXunta de Galicia; ED481D-2021-020
dc.description.sponsorshipinfo:eu-repo/grantAgreement/ISCIII/Programa Estatal de Generación de Conocimiento y Fortalecimiento del Sistema Español de I+D+I/PI20%2F00497/ES/TERAPIA CELULAR CON MICRO ARN Y VESICULAS EXTRACELULARES PARA EL TRATAMIENTO DE LA INFLAMACION CRONICA EN UN MODELO DE OA. (TERAPIA LIBRE DE CELULAS)
dc.identifier.citationMato-Basalo R, Lucio-Gallego S, Alarcón-Veleiro C, Sacristán-Santos M, Quintana MDPM, Morente-López M, de Toro FJ, Silva-Fernández L, González-Rodríguez A, Arufe MC, Labora JAF. Action mechanisms of small extracellular vesicles in inflammaging. Life (Basel). 2022 Apr 6;12(4):546.es_ES
dc.identifier.doi10.3390/life12040546
dc.identifier.issn2075-1729
dc.identifier.urihttp://hdl.handle.net/2183/30642
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation.urihttps://doi.org/10.3390/life12040546es_ES
dc.rightsCreative Commons Attribution 4.0 International License (CC-BY 4.0)es_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCellular senescencees_ES
dc.subjectInflammaginges_ES
dc.subjectsEVses_ES
dc.subjectSenomorphicses_ES
dc.titleAction mechanisms of small extracellular vesicles in inflammaginges_ES
dc.typejournal articlees_ES
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery1009ec06-73cd-418b-8262-a8a37d999e8e

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