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http://hdl.handle.net/2183/30642 Action mechanisms of small extracellular vesicles in inflammaging
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Lucio-Gallego, Sergio
Alarcón Veleiro, Carmen
Sacristán-Santos, Marta
Miranda Quintana, María del Pilar
Morente-López, Miriam
Silva-Fernández, Lucía
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Mato-Basalo R, Lucio-Gallego S, Alarcón-Veleiro C, Sacristán-Santos M, Quintana MDPM, Morente-López M, de Toro FJ, Silva-Fernández L, González-Rodríguez A, Arufe MC, Labora JAF. Action mechanisms of small extracellular vesicles in inflammaging. Life (Basel). 2022 Apr 6;12(4):546.
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Abstract
[Abstract] The accumulation process of proinflammatory components in the body due to aging influences intercellular communication and is known as inflammaging. This biological mechanism relates the development of inflammation to the aging process. Recently, it has been reported that small extracellular vesicles (sEVs) are mediators in the transmission of paracrine senescence involved in inflammatory aging. For this reason, their components, as well as mechanisms of action of sEVs, are relevant to develop a new therapy called senodrugs (senolytics and senomorphic) that regulates the intercellular communication of inflammaging. In this review, we include the most recent and relevant studies on the role of sEVs in the inflammatory aging process and in age-related diseases such as cancer and type 2 diabetes.
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This article belongs to the Special Issue Extracellular Vesicles Research in Inflamm-Aging
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Except where otherwise noted, this item's license is described as Creative Commons Attribution 4.0 International License (CC-BY 4.0)