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Syzygium aromaticum (clove) and Thymus zygis (thyme) essential oils increase susceptibility to colistin in the nosocomial pathogens Acinetobacter baumannii and Klebsiella pneumoniae
dc.contributor.author | Poza, Margarita | |
dc.contributor.author | Vázquez-Ucha, Juan Carlos | |
dc.contributor.author | Martínez-Guitián, Marta | |
dc.contributor.author | Lasarte-Monterrubio, Cristina | |
dc.contributor.author | Conde-Pérez, Kelly | |
dc.contributor.author | Arca-Suárez, Jorge | |
dc.contributor.author | Álvarez-Fraga, Laura | |
dc.contributor.author | Pérez Gómez, Astrid | |
dc.contributor.author | Crecente-Campo, José | |
dc.contributor.author | Alonso, María J. | |
dc.contributor.author | Bou, Germán | |
dc.contributor.author | Beceiro, Alejandro | |
dc.date.accessioned | 2024-08-14T10:34:23Z | |
dc.date.available | 2024-08-14T10:34:23Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Vázquez-Ucha, J. C., Martínez-Guitián, M., Lasarte-Monterrubio, C., Conde-Pérez, K., Arca-Suárez, J., Álvarez-Fraga, L., Pérez, A., Crecente-Campo, J., Alonso, M. J., Bou, G., Poza, M., & Beceiro, A. (2020). Syzygium aromaticum (clove) and Thymus zygis (thyme) essential oils increase susceptibility to colistin in the nosocomial pathogens Acinetobacter baumannii and Klebsiella pneumoniae. Biomedicine and Pharmacotherapy, 130. https://doi.org/10.1016/J.BIOPHA.2020.110606 | es_ES |
dc.identifier.uri | http://hdl.handle.net/2183/38594 | |
dc.description.abstract | [Abstract] The discovery of new antibiotics that are effective against Acinetobacter baumannii and Enterobacteralesis a research priority. Several essential oils (EOs) have displayed some antimicrobial activity and could potentially act as antibiotic adjuvants. Research in this area aims to develop new therapeutic alternatives to treat infections caused by these pathogens. MICs of different EOs were determined against A. baumannii and Klebsiella pneumoniae. Combined disk diffusion tests and checkerboard assays were used to study the synergy between the EOs and antibiotics. The fractional inhibitory concentration index (FICindex) was calculated in order to categorize the interaction. Time-kill assays were also performed. The EOs that displayed the highest levels of antimicrobial activity were clove (Syzygium aromaticum L.) and thyme (Thymus zygis L.). Combined disk diffusion tests and checkerboard assays revealed synergy between these EOs and colistin. Addition of either clove or thyme EO decreased the MIC of colistin by 8- to 64-fold and 8- to 128-fold in the colistin-resistant A. baumannii and K. pneumoniae strains, respectively (FICindex ≤ 0.5, synergy). MICs were also reduced in the colistin-susceptible strains. Time-kill assays also indicated the strong activity of the combined therapy. In summary, the use of clove or thyme EO in combination with colistin could improve the efficacy of the antibiotic and significantly reduce the concentrations needed to inhibit growth of A. baumannii and K. pneumoniae. | es_ES |
dc.description.sponsorship | Funding: This study was funded by projects IN607A 2016/22 (GAIN), PI15/00860, PI18/00501 and REIPI RD16/0016/006 (co-financed by the European Development Regional Fund "A way to achieve Europe" and the operative Intelligent Growth program 2014-2020) awarded to GB, PI14/00059 and PI17/01482 awarded to AB and MP (Instituto de Salud Carlos III). JCVU was financially supported the pFIS Programme (FI18/00315, ISCIII), MMG by a Clara Roy grant (SEIMC), KCP by IN607A 2016/22 (GAIN), CLM by IN606A-2019/029 (GAIN) and JAS by the Rio Hortega program (CM19/00219, ISCIII) and the FPNS (post-specialization grant). Acknowledgements: We thank Dr J.D. Boyce for the kind gift of ATCC19606ΔlpxC. We also thank Dr S. Pournaras for the kind gift of AB248 and AB249. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PI18%2F00501/ES/DISEÑO Y DESARROLLO DE UNA VACUNA PARA LA PREVENCION Y ERRADICACION DE LAS INFECCIONES RESPIRATORIAS AGUDAS Y CRONICAS (FIBROSIS QUISTICA) CAUSADAS POR PSEUDOMONAS AERUGINOSA | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/RD16%2F0016%2F006/ES/RED ESPAÑOLA DE INVESTIGACIÓN EN PATOLOGÍAS INFECCIOSAS/ | es_ES |
dc.relation | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PI17%2F01482/ES/EVALUACION DE NUEVAS ESTRATEGIAS ANTIMICROBIANAS MEDIANTE SILENCIAMIENTO DE ARN VEHICULIZADO EN NANOCAPSULAS E INHIBIDORES ENZIMATICOS/ | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PI15%2F00860/ES/Desarrollo de una plataforma universal de vacunas bacterianas vivas atenuadas auxótrofas para D-glutamato: prevención y erradicación de infecciones por bacterias multirresistentes/ | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PI14%2F00059/ES/Nuevas estrategias frente al patógeno multirresistente Acinetobacter baumannii: silenciamiento (siRNA) bacteriano y nuevos inhibidores químicos. Evaluación en estudios preclínicos | es_ES |
dc.relation.uri | https://doi.org/10.1016/j.biopha.2020.110606 | es_ES |
dc.rights | CC BY-NC-ND 4.0 ATTRIBUTION-NONCOMMERCIAL-NODERIVATIVES 4.0 INTERNATIONAL | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | Essential oils | es_ES |
dc.subject | Nosocomial infection | es_ES |
dc.subject | Colistin | es_ES |
dc.subject | Multidrug-resistance | es_ES |
dc.subject | Acinetobacter baumannii | es_ES |
dc.subject | Klebsiella pneumoniae | es_ES |
dc.title | Syzygium aromaticum (clove) and Thymus zygis (thyme) essential oils increase susceptibility to colistin in the nosocomial pathogens Acinetobacter baumannii and Klebsiella pneumoniae | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | Biomedicine & Pharmacotherapy | es_ES |
UDC.volume | 130 | es_ES |
UDC.startPage | Article 110606 | es_ES |
dc.identifier.doi | 10.1016/j.biopha.2020.110606 |
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