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Regulation of visceral adipose tissue-derived serine protease inhibitor by nutritional status, metformin, gender and pituitary factors in rat white adipose tissue
dc.contributor.author | González, Carmen Ruth | |
dc.contributor.author | Caminos, Jorge Eduardo | |
dc.contributor.author | Vázquez, M.J. | |
dc.contributor.author | Garcés, María Fernanda | |
dc.contributor.author | Cepeda, Libia Alexandra | |
dc.contributor.author | Ángel, Alberto | |
dc.contributor.author | González, Adriana C. | |
dc.contributor.author | García-Renduelles, María E.R. | |
dc.contributor.author | Sangiao-Alvarellos, Susana | |
dc.contributor.author | López, Miguel Ángel | |
dc.date.accessioned | 2024-06-26T10:47:32Z | |
dc.date.available | 2024-06-26T10:47:32Z | |
dc.date.issued | 2009-07-14 | |
dc.identifier.citation | González CR, Caminos JE, Vázquez MJ, Garcés MF, Cepeda LA, Angel A, González AC, García-Rendueles ME, Sangiao-Alvarellos S, López M, Bravo SB, Nogueiras R, Diéguez C. Regulation of visceral adipose tissue-derived serine protease inhibitor by nutritional status, metformin, gender and pituitary factors in rat white adipose tissue. J Physiol. 2009 Jul 15;587(Pt 14):3741-50. | es_ES |
dc.identifier.issn | 0022-3751 | |
dc.identifier.uri | http://hdl.handle.net/2183/37412 | |
dc.description.abstract | [Abstract] Visceral adipose tissue-derived serine protease inhibitor (vaspin) is a recently discovered adipocytokine mainly secreted from visceral adipose tissue, which plays a main role in insulin sensitivity. In this study, we have investigated the regulation of vaspin gene expression in rat white adipose tissue (WAT) in different physiological (nutritional status, pregnancy, age and gender) and pathophysiological (gonadectomy, thyroid status and growth hormone deficiency) settings known to be associated with energy homeostasis and alterations in insulin sensitivity. We have determined vaspin gene expression by real-time PCR. Vaspin was decreased after fasting and its levels were partially recovered after leptin treatment. Chronic treatment with metformin increased vaspin gene expression. Vaspin mRNA expression reached the highest peak at 45 days in both sexes after birth and its expression was higher in females than males, but its levels did not change throughout pregnancy. Finally, decreased levels of growth hormone and thyroid hormones suppressed vaspin expression. These findings suggest that WAT vaspin mRNA expression is regulated by nutritional status, and leptin seems to be the nutrient signal responsible for those changes. Vaspin is influenced by age and gender, and its expression is increased after treatment with insulin sensitizers. Finally, alterations in pituitary functions modify vaspin levels. Understanding the molecular mechanisms regulating vaspin will provide new insights into the pathogenesis of the metabolic syndrome. | es_ES |
dc.description.sponsorship | This work has been supported by grants from Xunta de Galicia (M.L.: GRC2006/66), Fondo Investigationes Sanitarias (M.L.: PI061700), Ministerio de Educacion y Ciencia (C.D.: BFU2008, M.L.: RYC-2007-00211, R.N.: RYC-2008-02219), Mútua Madrileña (C.D. and M.L.), European Union (Health-F2-2008-223713), Faculty of Medicine and Dirección de Investigaciones Sede Bogotá– Universidad Nacional de Colombia. | es_ES |
dc.description.sponsorship | Xunta de Galicia; GRC2006/66 | es_ES |
dc.description.sponsorship | Instituto de Salud Carlos III; PI061700 | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/MICINN/Programa Nacional de Investigación Fundamental/BFU2008-01728/ES/CARACTERIZACION MECANISTICA Y FUNCIONAL DE LAS SEÑALES COMPARTIMENTALIZADAS DE RAS | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/MEC/RYC-2007-00211/ES/ | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/MICINN/Programa Nacional de Contratación e Incorporación/RYC-2008-02219/ES/ | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | John Wiley & Sons | es_ES |
dc.relation.uri | https://doi.org/10.1113/jphysiol.2009.172510 | es_ES |
dc.rights | This is the peer reviewed version of the following article, which has been published in final form at Wiley Online Library. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited | es_ES |
dc.subject | Aging | es_ES |
dc.subject | Gene expression regulation | es_ES |
dc.subject | Intra-abdominal fat | es_ES |
dc.subject | Metformin | es_ES |
dc.subject | Nutritional status | es_ES |
dc.subject | Pregnancy, Animal | es_ES |
dc.subject | Serine proteinase inhibitors | es_ES |
dc.title | Regulation of visceral adipose tissue-derived serine protease inhibitor by nutritional status, metformin, gender and pituitary factors in rat white adipose tissue | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | The Journal of Physiology | es_ES |
UDC.volume | 587 | es_ES |
UDC.issue | 14 | es_ES |
UDC.startPage | 3741 | es_ES |
UDC.endPage | 3750 | es_ES |
dc.identifier.doi | 10.1113/jphysiol.2009.172510 |
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