Now showing items 1-7 of 7

    • A meta-analysis and a functional study support the influence of mtDNA variant m.16519C on the risk of rapid progression of knee osteoarthritis 

      Durán-Sotuela, Alejandro; Fernández-Moreno, Mercedes; Suárez-Ulloa, Victoria; Vázquez-García, Jorge; Relaño, Sara; Hermida-Gómez, Tamara; Balboa-Barreiro, Vanesa; Lourido-Salas, Lucía; Calamia, Valentina; Fernández-Puente, Patricia; Ruiz-Romero, Cristina; Fernández-Tajes, Juan; Vaamonde-García, Carlos; de Andrés, María C.; Oreiro, Natividad; Blanco García, Francisco J; Rego-Pérez, Ignacio (BMJ, 2023-04-06)
      [Abstract] Objectives: To identify mitochondrial DNA (mtDNA) genetic variants associated with the risk of rapid progression of knee osteoarthritis (OA) and to characterise their functional significance using a cellular ...
    • Anti-inflammatory activity of APPA (Apocynin and Paeonol) in human articular chondrocytes 

      Fernández-Moreno, Mercedes; Hermida-Gómez, Tamara; Larkins, Nicholas; Reynolds, Alan; Blanco García, Francico J (MDPI, 2024-01-16)
      [Abstract] Osteoarthritis (OA) is a chronic joint disease leading to cartilage loss and reduction in the joint space which results in pain. The current pharmacological treatment of OA is inadequate and pharmacological ...
    • Generation of human immortalized chondrocytes from osteoarthritic and healthy cartilage 

      Piñeiro-Ramil, María; Sanjurjo-Rodríguez, Clara; Rodríguez-Fernández, Silvia; Hermida-Gómez, Tamara; Blanco García, Francisco J; Fuentes Boquete, Isaac Manuel; Vaamonde-García, Carlos; Díaz-Prado, Silvia (The British Editorial Society of Bone & Joint Surgery, 2023-01-17)
      [Abstract] Aims. After a few passages of in vitro culture, primary human articular chondrocytes undergo senescence and loss of their phenotype. Most of the available chondrocyte cell lines have been obtained from cartilage ...
    • Histone extraction from human articular cartilage for the study of epigenetic regulation in osteoarthritis 

      Núñez-Carro, Carmen; Blanco-Blanco, Margarita; Montoya, Tatiana; Villagrán-Andrade, Karla M.; Hermida-Gómez, Tamara; Blanco García, Francisco J; De Andrés, María C. (MDPI, 2022-03-20)
      [Abstract] Osteoarthritis (OA) is a chronic disease that affects articular cartilage, causing its degeneration. Although OA is one of the most prevalent pathologies globally, there are no definitive treatments available. ...
    • Mesenchymal stem cells from human amniotic membrane 

      Sanjurjo-Rodríguez, Clara; Díaz-Prado, Silvia; Hermida-Gómez, Tamara; Fuentes Boquete, Isaac Manuel; Blanco García, Francisco J (Springer, 2014)
      [Abstract] The human amnion or amniotic membrane (HAM) has emerged as a novel and alternative source of stem cells. This tissue presents a reservoir of two types of stem cells from different embryological origins: human ...
    • Mitochondrial role on cellular apoptosis, autophagy, and senescence during osteoarthritis pathogenesis 

      Dalmao-Fernández, Andrea; Hermida-Gómez, Tamara; Nogueira-Recalde, Uxía; Rego-Pérez, Ignacio; Blanco García, Francisco J; Fernández-Moreno, Mercedes (MDPI, 2024-06-04)
      [Abstract] Authors have demonstrated that apoptosis activation is a pathway related to cartilage degradation characteristics of the OA process. Autophagy is an adaptive response to protect cells from various environmental ...
    • Reduced levels of H₂S in diabetes-associated osteoarthritis are linked to hyperglycaemia, Nrf-2/HO-1 signalling downregulation and chondrocyte dysfunction 

      Piñeiro-Ramil, María; Burguera, Elena F.; Hermida-Gómez, Tamara; Caramés, Beatriz; Oreiro, Natividad; Meijide-Faílde, Rosa; Blanco García, Francisco J; Vaamonde-García, Carlos (MDPI, 2022-03-25)
      [Abstract] Different findings indicate that type 2 diabetes is an independent risk factor for osteoarthritis (OA). However, the mechanisms underlying the connection between both diseases remain unclear. Changes in the ...