Rodríguez, JéssicaPérez-González, Daniel CibránMartínez-Calvo, MiguelMosquera Mosquera, JesúsMascareñas, José2024-10-252024-10-252022-01-26RSC Adv., 2022, 12, 35002046-2069http://hdl.handle.net/2183/39817[Abstract]: Herein, we describe an approach for the on-demand disassembly of dimeric peptides using a palladium-mediated cleavage of a designed self-immolative linker. The utility of the strategy is demonstrated for the case of dimeric basic regions of bZIP transcription factors. While the dimer binds designed DNA sequences with good affinities, the peptide–DNA complex can be readily dismounted by addition of palladium reagents that trigger the cleavage of the spacer, and the release of unfunctional monomeric peptides.eng© 2022 The Author(s). Published by the Royal Society of Chemistry. This Open Access Article is licensed under a Creative Commons Attribution-Non Commercial 3.0 Unported Licence (http://creativecommons.org/licenses/by-nc/3.0/).http://creativecommons.org/licenses/by-nc/3.0/es/DimersDNA complexDNA-bindingPalladiumTranscriptionBinding peptidebZIP transcription factorsPalladium mediatedSelf-immolativejournal articleopen access10.1039/D1RA09180H