Ávila-Álvarez, AlejandroPértega-Díaz, SoniaVázquez Gómez, LorenaSucasas Alonso, AndreaRomero Rey, HenarEiriz Barbeito, DoloresCabana Vázquez, Montserrat2024-04-092024-04-092020-05Avila-Alvarez A, Pertega-Diaz S, Vazquez Gomez L, Sucasas Alonso A, Romero Rey H, Eiriz Barbeito D, Cabana Vazquez M. Pain assessment during eye examination for retinopathy of prematurity screening: Skin conductance versus PIPP-R. Acta Paediatr. 2020 May;109(5):935-942.0803-5253http://hdl.handle.net/2183/36106Observational study[Abstract] Aim: To assess changes in skin conductance during retinopathy of prematurity screening and to study the correlation between the skin conductance and a validated pain scale. Methods: Prospective observational study. Fifty-three eye examinations were performed in 32 preterm infant candidates for retinopathy of prematurity screening. Outcome measures were changes in Premature Infant Pain Profile-Revised (PIPP-R) scale and number of skin conductance fluctuations. Results: There was a significant increase from baseline in the number of skin conductance fluctuations and PIPP-R during the procedure. The maximum value of number of skin conductance fluctuations was 0.64 ± 0.44 peaks/sec, and the maximum value of PIPP-R was 10.8 ± 3.3. A correlation between the skin conductance and PIPP-R was not found at any time during the eye examination. Repeated measures correlation analyses showed only a moderate positive correlation between PIPP-R and number of skin conductance fluctuation values. Conclusion: There were significant changes in both PIPP-R and number of skin conductance fluctuations during retinopathy of prematurity screening, reaffirming that this procedure is painful and stressful. The number of skin conductance fluctuations and PIPP-R are not significantly correlated, which likely reflects that these parameters evaluate different but complementary aspects of neonatal pain responses.engThis is the pre-peer reviewed version of the article which has been published in final form at Acta Paediatrica. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.PainPremature infantsRetinopathy of prematuritySkin conductanceStressjournal articleopen access