Antón-Aparicio, Luis M.Cassinello Espinosa, J.García Campelo, RosarioGómez Veiga, FranciscoDíaz-Prado, SilviaAparicio Gallego, Guadalupe2018-08-232018-08-232007-02Antón Aparicio LM, Cassinello Espinosa J, García Campelo R, Díaz Prado S, Aparicio Gallego G. Prostate carcinoma and stem cells. Clin Transl Oncol. 2007; 9(2):66-761699-048X1699-3055http://hdl.handle.net/2183/20974[Abstract] Stem cells, as classically defined, are cells with a capacity to self-renew and to generate daughter cells that can differentiate down several cell lineages to form all of the cell types that are found in the mature tissue. Stem cells and tumour cells have many similar features, including infinite lifespan, self-renewal, multidrug resistance, telomerase expression and, in the instance of the prostate, androgen independence. Evidence supports a role for stem cells in the etiology of many types of cancer. The evolution of androgen-independent prostate carcinoma may reflect the emergence of stemlike prostate tumour cells. Because cancer may be a disease of stem cell lineages and Shh-Gli signalling controls the behaviour of precursors and of cells with stem cell properties in the mammalian tissues, prostate cancer might derive from inappropriate expansion of prostatic epithelial stem cell lineages caused by abnormal Shh-Gli function. This review attempts to integrate these recent results.engThe final publication is avaliable at Springer LInkStem cellsProstate cancerWNT and Hh pathwayjournal articleopen access