Merino Carballeira, MaríaAcosta Barriga, JoshiPoza, MargaritaSanz, FranciscaBeceiro Casas, AlejandroChaves Sánchez, FernandoBou, Germán2026-03-102026-03-102010-06-01Merino MAcosta JPoza M, Sanz F, Beceiro A, Chaves F, Bou G2010.OXA-24 Carbapenemase Gene Flanked by XerC/XerD-Like Recombination Sites in Different Plasmids from Different Acinetobacter Species Isolated during a Nosocomial Outbreak. Antimicrob Agents Chemother54:.https://doi.org/10.1128/aac.01674-090066-48041098-6596https://hdl.handle.net/2183/47705[Abstract] A clinical strain of Acinetobacter calcoaceticus resistant to carbapenems was isolated from a blood culture sample from an inpatient in a hospital in Madrid (Spain) during a large outbreak of infection (affecting more than 300 inpatients), caused by a multidrug-resistant Acinetobacter baumannii clone. The carbapenem resistance in both the A. calcoaceticus and A. baumannii clones was due to a blaOXA-24 gene harbored in different plasmids. The plasmids were fully sequenced, revealing the presence of site-specific recombination binding sites putatively involved in mobilization of the blaOXA-24 gene. Comparison of plasmids contained in the two strains revealed possible horizontal transmission of resistance genes between the Acinetobacter species.eng© 2010 American Society for Microbiology.Antibiotic ResistanceAntimicrobial ResistanceBacteriologyBeta-lactam ResistanceClinical Microbiology and Infectious DiseasesDrug Resistant PathogensEnzymatic Inactivation of AntibioticsEvolution of Antibiotic ResistanceMicrobial Physiology and GeneticsPlasmidsjournal articleopen access10.1128/aac.01674-09