Fernández-García, LauraFernández-Cuenca, FelipeBlasco, LucíaLópez-Rojas, RafaelAmbroa, AntónZamora López, María JoséPascual, ÁlvaroBou, GermánTomás, María2025-03-242025-03-242018-04-26Fernández-García L, Fernandez-Cuenca F, Blasco L, López-Rojas R, Ambroa A, Lopez M, Pascual Á, Bou G, Tomás M. Relationship between tolerance and persistence mechanisms in acinetobacter baumannii strains with AbkAB toxin-antitoxin system. Antimicrob Agents Chemother. 2018 Apr 26;62(5):e00250-18.0066-4804http://hdl.handle.net/2183/41513[Abstract] The molecular mechanisms of tolerance and persistence associated with several compounds in Acinetobacter baumannii clinical isolates are unknown. Using transcriptomic and phenotypic studies, we found a link between mechanisms of bacterial tolerance to chlorhexidine and the development of persistence in the presence of imipenem in an A. baumannii strain belonging to clinical clone ST-2 (OXA-24 β-lactamase and AbkAB toxin-antitoxin [TA] system carried in a plasmid). Interestingly, the strain A. baumannii ATCC 17978 (AbkAB TA system from plasmid) showed persistence in the presence of imipenem and chlorhexidine.engCreative Commons Attribution 4.0 International License (CC-BY 4.0)http://creativecommons.org/licenses/by/3.0/es/TolerancePersistenceChlorhexidineImiperemAcinetobacterToxin-antioxinjournal articleopen access10.1128/AAC.00250-18