Jonkman, Nini H.Westland, HeleenGroenwold, Rolf H.H.Agren, SusannaAnguita, ManuelBlue, LyndaBrugging-André de la Porte, Pieta W.F.DeWalt, Darren A.Hebert, Paul L.Heisler, MicheleJaarsma, TinyKempen, Gertrudis I.J.M.Leventhal, Marcia E.Lok, Dirk J.A.Martensson, JanMuñiz, JavierOtsu, HarukaPeters-Klimm, FrankRich, Michael W.Riegel, BarbaraStrömberg, AnnaTsuyuki, Ross T.Trappenburg, Jaap C.A.Schuurmans, Marieke J.Hoes, Arno2025-05-122025-05-122016-11Jonkman NH, Westland H, Groenwold RH, Ågren S, Anguita M, Blue L, Bruggink-André de la Porte PW, DeWalt DA, Hebert PL, Heisler M, Jaarsma T, Kempen GI, Leventhal ME, Lok DJ, Mårtensson J, Muñiz J, Otsu H, Peters-Klimm F, Rich MW, Riegel B, Strömberg A, Tsuyuki RT, Trappenburg JC, Schuurmans MJ, Hoes AW. What are effective program characteristics of self-management interventions in patients with heart failure?: an individual patient data meta-analysis. J Card Fail. 2016 Nov;22(11):861-871.1071-9164http://hdl.handle.net/2183/41960Review[Abstract] Background: To identify those characteristics of self-management interventions in patients with heart failure (HF) that are effective in influencing health-related quality of life, mortality, and hospitalizations. Methods and results: Randomized trials on self-management interventions conducted between January 1985 and June 2013 were identified and individual patient data were requested for meta-analysis. Generalized mixed effects models and Cox proportional hazard models including frailty terms were used to assess the relation between characteristics of interventions and health-related outcomes. Twenty randomized trials (5624 patients) were included. Longer intervention duration reduced mortality risk (hazard ratio 0.99, 95% confidence interval [CI] 0.97-0.999 per month increase in duration), risk of HF-related hospitalization (hazard ratio 0.98, 95% CI 0.96-0.99), and HF-related hospitalization at 6 months (risk ratio 0.96, 95% CI 0.92-0.995). Although results were not consistent across outcomes, interventions comprising standardized training of interventionists, peer contact, log keeping, or goal-setting skills appeared less effective than interventions without these characteristics. Conclusion: No specific program characteristics were consistently associated with better effects of self-management interventions, but longer duration seemed to improve the effect of self-management interventions on several outcomes. Future research using factorial trial designs and process evaluations is needed to understand the working mechanism of specific program characteristics of self-management interventions in HF patients.engCreative Commons Attribution 4.0 International License (CC-BY 4.0)http://creativecommons.org/licenses/by/3.0/es/Heart failureIndividual patient data meta-analysisSelf-managementreviewopen access10.1016/j.cardfail.2016.06.422