Blanco, MoisésTarrío, NuriaReboredo, MargaritaHaz, MarGarcía, JorgeQuindós-Varela, MaríaFigueroa, AngélicaAntón-Aparicio, Luis M.Calvo, LourdesValladares-Ayerbes, Manuel2019-02-202019-02-202014-06-20Blanco-Calvo M, Tarrío N, Reboredo M, et al. Circulating levels of GDF15, MMP7 and miR-200c as a poor prognostic signature in gastric cancer. Future Oncol. 2014; 10(7): 1187-12021479-6694http://hdl.handle.net/2183/21886[Abstract] Aim: To analyze GDF15 and MMP7 serum levels as diagnostic biomarkers in gastric cancer (GC) patients. The prognostic value of GDF15 and MMP7 serum levels in combination with miR-200c blood expression was also analyzed. Patients & methods: Fifty-two GC and 23 control samples were included. Results: GDF15 and MMP7 proved to be powerful tools for GC diagnosis. Increased levels of GDF15 and MMP7 were associated with shorter progression-free survival and overall survival in univariate analysis. In multivariate analysis, the combination of high levels of GDF15, MMP7 and miR-200c was an independent predictor for death (p = 0.033). Conclusion: GDF15 and MMP7 serum levels have diagnostic value for GC. The combination marker formed by GDF15, MMP7 and miR-200c is indicative of adverse evolution in GC patients.engBiomarkerDiagnosticGastric cancerGDF15MetastasismiR-200cMMP7Prognosticjournal articleopen access