Cortón, PabloNovo, PaulaLópez Sobrado, VanesaGarcía, Marcos D.Peinador, CarlosPazos, Elena2024-10-082024-10-082020-02Cortón, P. N., Paula; López-Sobrado, Vanesa; García, Marcos D. ;. Peinador, Carlos; Pazos, Elena Synthesis 2020, 52, 537.1437-210X0039-7881http://hdl.handle.net/2183/39488Author accepted manuscript[Abstract] We present herein the development of a new synthetic strategy for the conjugation of 4,4′-bipyridinium derivatives into peptide scaffolds. The methodology, based on the development of a solid-phase version of the Zincke reaction between activated pyridinium salts and amines, is able to produce the desired conjugates in a straightforward fashion, with the bipyridinium units attached at the N-terminus of peptides or at Lys side chains of N-terminal acetylated peptides.engPeptide-based conjugatesViologensZincke reactionSolid Phase Peptide Synthesis (SPPS)Synthetic methodologyjournal articleopen access10.1055/s-0039-1690016