Amino Acid–Viologen Hybrids: Synthesis, Cucurbituril Host–Guest Chemistry, and Implementation on the Production of Peptides

Barravecchia Prado, Liliana InésNeira, IagoPazos, ElenaPeinador, CarlosGarcía, Marcos D.2022-03-082022-03-082021-12-10Barravecchia, L.; Neira, I.; Pazos, E.; Peinador, C.; García, M. D. Amino Acid–Viologen Hybrids: Synthesis, Cucurbituril Host–Guest Chemistry, and Implementation on the Production of Peptides. J. Org. Chem. 2022, 87, 1, 760–764. https://doi.org/10.1021/acs.joc.1c020400022-32631520-6904http://hdl.handle.net/2183/29896Financiado para publicación en acceso aberto: Universidade da Coruña/CISUG[Abstract] We present herein the development of a series of viologen–amino acid hybrids, obtained in good yields either by successive alkylations of 4,4′-bipyridine, or by Zincke reactions followed by a second alkylation step. The potential of the obtained amino acids has been exemplified, either as typical guests of the curcubituril family of hosts (particularly CB[7]/[8]) or as suitable building blocks for the solution/solid-phase synthesis of two model tripeptides with the viologen core inserted within their sequences.engAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Amino Acid–Viologen Hybrids: Synthesis, Cucurbituril Host–Guest Chemistry, and Implementation on the Production of Peptidesjournal articleopen access