Quintas, SoniaZapata-Wainberg, GustavoArias Rivas, SusanaXiménez-Carrillo, ÁlvaroCastillo, JoséBenavente-Fernández, LorenaMasjuan, JaimeFreijo Guerrero, María del MarÉgido, JoséGarcía Pastor, AndrésCardona, PereLago, AidaCastellanos, María del MarFuentes, BlancaSobrado, MónicaVivancos, José2024-12-192024-12-192020-12-15Quintas S, Zapata-Wainberg G, Arias-Rivas S, Ximénez-Carrillo Á, Castillo J, Benavente Fernández L, Masjuan Vallejo J, Freijó Guerrero MDM, Egido J, García Pastor A, Cardona P, Lago A, Castellanos Rodrigo M, Fuentes B, Sobrado M, Vivancos J. Time trends in intracerebral hemorrhage associated with oral anticoagulation and its risks factors in Spain from 2008 to 2015. Eur Neurol. 2021;84(1):16-21.0014-3022http://hdl.handle.net/2183/40554[Abstract] Background: Intracerebral hemorrhage (ICH) is 7- to 10-fold higher in anticoagulated patients. Given the more extended use of oral anticoagulants, an increase in the prevalence of ICH associated with oral anticoagulation (ICH-OAC) could be expected. However, there is no previous study that assesses the time trends of ICH-OAC in Spain. Methods: We conducted a combined data analysis after creating a joint database of the 3 most important epidemiological studies on ICH-OAC of our country: the EPICES study (2008–2009), the TAC Registry (TR) study (2012–2013) and the TAC Registry 2 (TR2) study (2015). We finally included 65, 235, and 366 patients from the EPICES, TR, and TR2 studies, respectively. Results: We have observed a 3.73-fold increase in the crude annual incidence of ICH-OAC throughout the period of study, with proportion of ICH-OAC out of total ICH increasing from 8.4% in 2008 to 18.2% in 2015. Age, dyslipidemia, and prior antiplatelet treatment increased during the study, but we found no statistically significant differences in other risk factors for ICH-OAC. Conclusions: The incidence of ICH-OAC is increasing in our country. It might at least be partly explained by aging of the population, with mean age at presentation being higher in the last years.engThis is the accepted manuscript version of an article published by Karger Publishers in European Neurology.Intracerebral hemorrhageOral anticoagulantsDirect oral anticoagulantsVitamin K antagonistsIncidencejournal articleopen access10.1159/000511603