Hou, HuileiCardo, LuciaMancino, DonatoArnaiz, BlancaCriado, AlejandroPrato, Maurizio2024-06-272024-06-272020-11-25Nanoscale, 2020, 12, 238242040-3372http://hdl.handle.net/2183/37510[Abstract] Graphene-based materials are particularly suitable platforms for the development of new systems able to release drugs upon the application of controlled electrochemical stimuli. Herein, we report a new electro-responsive graphene carrier functionalised with aldehydes (as drug models) through imine-based linkers. We explore a new type of drug loading/release combination based on the formation of a covalent bond and its cleavage upon electrolysis. The new graphene–drug model hybrid is stable under physiological conditions and displays a fast drug release upon the application of low voltages.engAtribución-NoComercial 3.0https://creativecommons.org/licenses/by-nc/3.0/GraphenePhysiological modelsTargeted drug deliveryCovalent bondDrug LiberationIminesjournal articleopen access10.1039/D0NR04102E