González Montoro, Aldana MaríaCao, RicardoFaes, ChristelMolenberghs, GeertEspinosa, NelsonCudeiro, JavierMariño Alfonso, Xurxo2015-05-182015-05-182014-02González Montoro AM, Cao R, Faes C, Molenberghs G, Espinosa N, Cudeiro J, Mariño J. Cross nearest-spike interval based method to measure synchrony dynamics. Math Biosci Eng. 2014;11(1):27-48http://hdl.handle.net/2183/14516[Abstract] A new synchrony index for neural activity is de ned in this paper. The method is able to measure synchrony dynamics in low ring rate scenarios. It is based on the computation of the time intervals between nearest spikes of two given spike trains. Generalized additive models are proposed for the synchrony pro les obtained by this method. Two hypothesis tests are proposed to assess for di erences in the level of synchronization in a real data example. Bootstrap methods are used to calibrate the distribution of the tests. Also, the expected synchrony due to chance is computed analytically and by simulation to assess for actual synchronization.engThis is a pre-copy-editing, author-produced PDF of an article accepted for publication in "Mathematical Biosciences and Engineering" following peer review.Generalized additive modelsBootstrapSleep-wakeSpontaneous activitySynchronizationjournal articleopen access