Jara, Luis M.Pérez-Varela, MaríaCorral, JordiArch, MartaCortés, PilarBou, GermánAranda Rodríguez, JesúsBarbé, Jordi2026-05-192026-05-192015-10-26Jara LM, Pérez-Varela M, Corral J, Arch M, Cortés P, Bou G, Aranda J, Barbé J. Novobiocin Inhibits the Antimicrobial Resistance Acquired through DNA Damage-Induced Mutagenesis in Acinetobacter baumannii. Antimicrob Agents Chemother. 2015 Oct 26;60(1):637-9.1098-6596https://hdl.handle.net/2183/48307Brief report[Abstract] Acinetobacter baumannii, a worldwide emerging nosocomial pathogen, acquires antimicrobial resistances in response to DNA-damaging agents, which increase the expression of multiple error-prone DNA polymerase components. Here we show that the aminocoumarin novobiocin, which inhibits the DNA damage response in Gram-positive bacteria, also inhibits the expression of error-prone DNA polymerases in this Gram-negative multidrug-resistant pathogen and, consequently, its potential acquisition of antimicrobial resistance through DNA damage-induced mutagenesis.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Acinetobacter baumanniiAnti-Bacterial AgentsBacterial ProteinsDNA RepairDNA-Directed DNA PolymeraseDrug Resistance, BacterialNovobiocinjournal articleopen access10.1128/AAC.01810-15