Sagastagoitia-Fornie, MartaMorán-Fernández, LauraBlázquez-Bermejo, ZorbaDíaz-Molina, BeatrizGómez-Bueno, ManuelAlmenar-Bonet, LuisLópez-Granados, AmadorGonzález-Vílchez, FranciscoMirabet, SoniaGarcía-Romero, ElenaSobrino-Márquez, José ManuelRábago Juan-Aracil, GregorioCastel-Lavilla, María A.Blasco-Peiró, TeresaGarrido-Bravo, Iris P.De la Fuente-Galán, LuisMuñiz, JavierCrespo-Leiro, María Generosa2023-10-202023-10-202023-05Sagastagoitia-Fornie M, Morán-Fernández L, Blázquez-Bermejo Z, Díaz-Molina B, Gómez-Bueno M, Almenar-Bonet L, López-Granados A, González-Vílchez F, Mirabet-Pérez S, García-Romero E, Sobrino-Márquez JM, Rábago Juan-Aracil G, Castel-Lavilla MA, Blasco-Peiro T, Garrido-Bravo I, De La Fuente-Galán L, Muñiz J, Crespo-Leiro MG. Incidence and prognosis of colorectal cancer after heart transplantation: data from the spanish post-heart transplant tumor registry. Transpl Int. 2023 May 19;36:11042.0934-0874http://hdl.handle.net/2183/33854Observational study[Abstract] In this observational and multicenter study, that included all patients who underwent a heart transplantation (HT) in Spain from 1984 to 2018, we analyzed the incidence, management, and prognosis of colorectal cancer (CRC) after HT. Of 6,244 patients with a HT and a median follow-up of 8.8 years since the procedure, 116 CRC cases (11.5% of noncutaneous solid cancers other than lymphoma registered) were diagnosed, mainly adenocarcinomas, after a mean of 9.3 years post-HT. The incidence of CRC increased with age at HT from 56.6 per 100,000 person-years among under 45 year olds to 436.4 per 100,000 person-years among over 64 year olds. The incidence rates for age-at-diagnosis groups were significantly greater than those estimated for the general Spanish population. Curative surgery, performed for 62 of 74 operable tumors, increased the probability of patient survival since a diagnosis of CRC, from 31.6% to 75.7% at 2 years, and from 15.8% to 48.6% at 5 years, compared to patients with inoperable tumors. Our results suggest that the incidence of CRC among HT patients is greater than in the general population, increasing with age at HT.engCreative Commons Attribution 4.0 International License (CC-BY 4.0)http://creativecommons.org/licenses/by/4.0/Colorectal cancerHeart transplantationIncidenceManagementPrognosisjournal articleopen access