Ruiz-Romero, CristinaFernández-Puente, PatriciaCalamia, ValentinaBlanco García, Francisco J2026-09-152026-09-152015-07-07Ruiz-Romero C, Fernández-Puente P, Calamia V, Blanco FJ. Lessons from the proteomic study of osteoarthritis. Expert Rev Proteomics. 2015 Aug;12(4):433-43.1744-8387https://hdl.handle.net/2183/49237Review[Abstract] Osteoarthritis is the most common rheumatic pathology and one of the leading causes of disability worldwide. It is a very complex disease whose etiopathogenesis is not fully understood. Furthermore, there are serious limitations for its management, since it lacks specific and sensitive biomarkers for early diagnosis, prognosis and therapeutic monitoring. Proteomic approaches performed in the last few decades have contributed to the knowledge on the molecular mechanisms that participate in this pathology and they have also led to interesting panels of putative biomarker candidates. In the next few years, further efforts should be made for translating these findings into the clinical routines. It is expected that targeted proteomics strategies will be highly valuable for the verification and qualification of biomarkers of osteoarthritis.engThis is an Accepted Manuscript of an article published by Taylor & Francis in Expert Review of Proteomics on 2015, available at: https://doi.org/10.1586/14789450.2015.1065182.BiomarkersCartilageChondrocytesJointOsteoarthritisProteomicsSynoviocytesSynoviumjournal articleopen access10.1586/14789450.2015.1065182