Esteve-Pastor, María AsunciónGarcía-Fernández, AmayaMacías, ManuelSegorb, FranciscoValdés, MarianoRoldán, VanessaMuñiz, JavierBadimón, LinaRoldán Rabadán, InmaculadaBertomeu-Martínez, VicenteCequier, ÁngelLip, Gregory Y.H.Anguita, ManuelMarín, Francisco2026-09-022026-09-022016-08-24Esteve-Pastor MA, García-Fernández A, Macías M, Sogorb F, Valdés M, Roldán V, Muñiz J, Badimon L, Roldán I, Bertomeu-Martínez V, Cequier Á, Lip GY, Anguita M, Marín F; FANTASIIA Investigators. Is the ORBIT bleeding risk score superior to the HAS-BLED score in anticoagulated atrial fibrillation patients? Circ J. 2016 Sep 23;80(10):2102-8.1347-4820https://hdl.handle.net/2183/49129Multicenter study[Abstract] Background: Several bleeding risk scores have been validated in patients with atrial fibrillation (AF). The ORBIT score has been recently proposed as a simple score with the best ability to predict major bleeding. The present study aimed to test the hypothesis that the ORBIT score was superior to the HAS-BLED score for predicting major bleeding and death in "real world" anticoagulated AF patients. Methods and results: We analyzed the predictive performance for bleeding and death of 406 AF patients who underwent 571 electrical cardioversion procedures and 1,276 patients with permanent/persistent AF from the FANTASIIA registry. In the cardioversion population, 21 patients had major bleeding events and 26 patients died. The predictive performance for major bleeding of HAS-BLED and ORBIT were not significantly different (c-statistics 0.77 (95% CI 0.66-0.88) and 0.82 (95% CI 0.77-0.93), respectively; P=0.080). For the FANTASIIA population, 46 patients had major bleeding events and 50 patients died. The predictive performances for major bleeding of HAS-BLED and ORBIT were not significantly different (c-statistics 0.63 (95% CI 0.56-0.71) and 0.70 (95% CI 0.62-0.77), respectively; P=0.116). For death, the predictive performances of HAS-BLED and ORBIT were not significantly different in both populations. The ORBIT score categorized most patients as "low risk". Conclusions: Despite the original claims in its derivation paper, the ORBIT score was not superior to HAS-BLED for predicting major bleeding and death in a "real world" oral anticoagulated AF population. (Circ J 2016; 80: 2102-2108).engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/AcenocoumarolAtrial fibrillationBleeding risk scoresElectrical cardioversionORBITjournal articleopen access10.1253/CIRCJ.CJ-16-0471