Madeira do O, J.Foralosso, R.Yilmaz, GokhanMastrotto, FrancescaKing, P.J.S.Xerri, R. M.He, YinfengWalle, Christopher van derFernández-Trillo, PacoLaughton, CharlesStyliari, Ioanna DanaiStolnik, Snjezana SnowMantovani, Giuseppe2024-07-112024-07-112019Madeira do O, J., Foralosso, R., Yilmaz, G., Mastrotto, F., King, P.J.S., Xerri, R.M., He, Y., Walle C.F. Van Der, Fernandez-Trillo, F., Laughton, C.A., Styliari, I., Stolnik, S. & Mantovani. G. (2019). Poly(triazolyl methacrylate) glycopolymers as potential targeted unimolecular nanocarriers. Nanoscale, 11(44), 21155-21166. https://doi.org/10.1039/C9NR05836Bhttp://hdl.handle.net/2183/37943[Abstract] Synthetic glycopolymers are increasingly investigated as multivalent ligands for a range of biological and biomedical applications. This study indicates that glycopolymers with a fine-tuned balance between hydrophilic sugar pendant units and relatively hydrophobic polymer backbones can act as single-chain targeted nanocarriers for low molecular weight hydrophobic molecules. Non-covalent complexes formed from poly(triazolyl methacrylate) glycopolymers and low molecular weight hydrophobic guest molecules were characterised through a range of analytical techniques – DLS, SLS, TDA, fluorescence spectroscopy, surface tension analysis – and molecular dynamics (MD) modelling simulations provided further information on the macromolecular characteristics of these single chain complexes. Finally, we show that these nanocarriers can be utilised to deliver a hydrophobic guest molecule, Nile red, to both soluble and surface-immobilised concanavalin A (Con A) and peanut agglutinin (PNA) model lectins with high specificity, showing the potential of non-covalent complexation with specific glycopolymers in targeted guest-molecule delivery.engCreative Commons Attribution 3.0 Unported Licencehttp://creativecommons.org/licenses/by/3.0/es/Poly(triazolyl methacrylate) glycopolymersTargeted unimolecular nanocarriersMethacrylatesMolecular dynamics simulationsjournal articleopen access10.1039/C9NR05836B