Novo, PaulaGarcía, Marcos D.Peinador, CarlosPazos, Elena2021-11-042021-11-042021-03-08Novo, P., García, M. D., Peinador, C. and Pazos, E. (2021) Reversible control of DNA binding with cucurbit[8]uril-induced supramolecular 4,4′-Bipyridinium–Peptide dimers. Bioconjugate chemistry. 32, 3, 507-511. https://doi.org/10.1021/acs.bioconjchem.1c000631043-18021520-4812http://hdl.handle.net/2183/28799Financiado para publicación en acceso aberto: Universidade da Coruña/CISUGThe Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.bioconjchem.1c00063[Abstract] Many cellular processes in living organisms are regulated by complex regulatory networks, built from noncovalent interactions between relatively few proteins that perform their functions by switching between homo- and heterooligomeric assemblies or mono- and bivalent states. Herein, we demonstrate that the conjugation of a 4,4′-bipyridinium scaffold to the basic region of the GCN₄ bZip transcription factor can be exploited to control the dimerization of the conjugate by formation of a supramolecular complex with cucurbit[8]uril. Importantly, this supramolecular complex is able to specifically recognize its target dsDNA, and this binding can be reversibly switched by the application of external stimuli.engAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/journal articleopen access10.1021/acs.bioconjchem.1c00063