Caminos, Jorge EduardoBravo López, Susana BelénGonzález, Carmen RuthGarcés, María FernandaCepeda, Libia AlexandraGonzález-Almario, Adriana C.Cordido, FernandoLópez, MiguelDiéguez, Carlos2026-07-072026-07-072008-04-02Caminos JE, Bravo SB, González CR, Garcés MF, Cepeda LA, González AC, Cordido F, López M, Diéguez C. Food-intake-regulating-neuropeptides are expressed and regulated through pregnancy and following food restriction in rat placenta. Reprod Biol Endocrinol. 2008 Apr 2;6:141477-7827https://hdl.handle.net/2183/48792[Abstract] Background: Neuropeptide Y (NPY), agouti related peptide (AgRP), cocaine and amphetamine-regulated transcript (CART) and melanocortins, the products of the proopiomelanocortin (POMC), are hypothalamic peptides involved in feeding regulation and energy homeostasis. Recent evidence has demonstrated their expression in rat and human placenta. Methods: In the current study, we have investigated the expression of those neuropeptides in the rat placenta by real-time PCR using a model of maternal food restriction. Results: Our results showed that placental-derived neuropeptides were regulated through pregnancy and following food restriction. Conclusion: These data could indicate that placental-derived neuropeptides represent a local regulatory circuit that may fine-tune control of energy balance during pregnancy.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Food DeprivationGene Expression RegulationHypothalamusMalnutritionNeuropeptidesPlacentaPregnancy, AnimalRatsjournal articleopen access10.1186/1477-7827-6-14