Pujales-Paradela, RosaSavic, TanjaBrandariz, IsabelPérez-Lourido, PauloAngelovski, GoranEsteban-Gómez, DavidPlatas-Iglesias, Carlos2022-03-182022-03-182019-03-11R. Pujales-Paradela, T. Savić, I. Brandariz, P. Pérez-Lourido, G. Angelovski, D. Esteban-Gómez and C. Platas-Iglesias, Reinforced Ni(II)-cyclam derivatives as dual 1H/19F MRI probes, Chem. Commun., 2019, 55, 4115–4118. DOI: 10.1039/C9CC01204D1364-548Xhttp://hdl.handle.net/2183/30055[Abstract] Reinforced cross-bridged Ni²⁺-cyclam complexes were functionalised with pendant arms containing both amide protons and CF₃ groups that lead to a dual ¹H/¹⁹F response. The resulting complexes possess very high inertness favourable for MRI applications. The paramagnetism of the Ni²⁺ ion shifts the amide resonance 56 ppm away from bulk water favouring the chemical exchange saturation transfer (CEST) effect and shortening the acquisition times in ¹⁹F magnetic resonance imaging (MRI) experiments, thus enhancing the signal-to-noise ratios compared to the fluorinated diamagnetic reference.engjournal articleopen access10.1039/C9CC01204D