Vaamonde-García, CarlosFlórez-Fernández, NoeliaTorres Pérez, María DoloresLamas Vázquez, María JoséBlanco García, Francisco JDomínguez, HerminiaMeijide-Faílde, Rosa2021-03-052021-01-26Vaamonde-García C, Flórez-Fernández N, Torres MD, Lamas-Vázquez MJ, Blanco FJ, Domínguez H, Meijide-Faílde R. Study of fucoidans as natural biomolecules for therapeutical applications in osteoarthritis. Carbohydr Polym. 2021 Apr 15;258:117692.0144-8617http://hdl.handle.net/2183/27425[Abstract] Osteoarthritis (OA) is the most prevalent articular chronic disease. Although, to date there is no cure for OA. Fucoidans, one of the main therapeutic components of brown algae, have emerged as promising molecules in OA treatment. However, the variability between fucoidans makes difficult the pursuit of the most suitable candidate to target specific pathological processes. By an in vitro experimental approach in chondrocytes and fibroblast-like synoviocytes, we observed that chemical composition of fucoidan, and specifically the phlorotannin content and the ratio sulfate:fucose, seems critically relevant for its biological activity. Nonetheless, other factors like concentration and molecular weight of the fucoidan may influence on its beneficial effects. Additionally, a cell-type dependent response was also detected. Thus, our results shed light on the potential use of fucoidans as natural molecules in the treatment of key pathological processes in the joint that favor the development of rheumatic disorders as OA.engCreative Commons Attribution-NonCommercial-NoDerivs 4.0 (CC-BY-NC-ND 4.0)http://creativecommons.org/licenses/by-nc-nd/4.0/Fucus vesiculosus fucoidanMacrocystis pyrifera fucoidanUndaria pinnatifida fucoidanOsteoarthritisOsteoarthritic chondrocytesSynovial fibroblastsjournal articleopen access