Aranda Rodríguez, JesúsLópez, MarioLeiva, EnoyMagán, AndrésAdler, BenBou, GermánBarbé, Jordi2026-09-242026-09-242014-02-19Aranda J, López M, Leiva E, Magán A, Adler B, Bou G, Barbé J. Role of Acinetobacter baumannii UmuD homologs in antibiotic resistance acquired through DNA damage-induced mutagenesis. Antimicrob Agents Chemother. 2014;58(3):1771-3.0066-4804https://hdl.handle.net/2183/49411[Abstract] The role of Acinetobacter baumannii ATCC 17978 UmuDC homologs A1S_0636-A1S_0637, A1S_1174-A1S_1173, and A1S_1389 (UmuDAb) in antibiotic resistance acquired through UV-induced mutagenesis was evaluated. Neither the growth rate nor the UV-related survival of any of the three mutants was significantly different from that of the wild-type parental strain. However, all mutants, and especially the umuDAb mutant, were less able to acquire resistance to rifampin and streptomycin through the activities of their error-prone DNA polymerases. Furthermore, in the A. baumannii mutant defective in the umuDAb gene, the spectrum of mutations included a dramatic reduction in the frequency of transition mutations, the mutagenic signature of the DNA polymerase V encoded by umuDC.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Acinetobacter baumanniiDNA Damagejournal articleopen access10.1128/AAC.02346-13