Le Fur, MarianeBeyler, MarylineMolnár, EniköFougère, OlivierEsteban-Gómez, DavidTircsó, GyulaPlatas-Iglesias, CarlosLepareur, NicolasRousseaux, OlivierTripier, Raphaël2018-11-282018-11-282017-09-07The role of the capping bond effect on pyclen natY3+/90Y3+ chelates: full control of the regiospecific N-functionalization makes the difference. M. Le Fur, M. Beyler, E. Molnár, O. Fougère, D. Esteban-Gómez, G. Tircsó, C. Platas-Iglesias, N. Lepareur, O. Rousseaux and R. Tripier, Chem. Commun., 2017, 53, 9534–9537.1359-73451364-548Xhttp://hdl.handle.net/2183/21395[Abstract] Thanks to a smart regiospecific N-functionalization, a pyclen based ligand bearing one picolinate and two acetate arms organized in a dissymmetric manner was synthesized for Y3+ complexation, and compared to its symmetric analogue. The nature of the capping bonds around the metal coordination environment has a dramatic effect on the properties of the chelate, the natY3+ and 90Y3+ dissymmetric derivatives presenting enhanced thermodynamic stability and kinetic inertness.engThermodynamic stabilityDFT calculationsYttrium complexesPyclen ligandsRadiotherapyjournal articleopen access