Camarena, MaríaBoada, YadiraPicó, JesúsCarbonell, Pablo2021-08-262021-08-262021Camarena, M., Boada, Y., Picó, J., Carbonell, P. Gene variant space for biosensor-based dynamic regulation. En XLII Jornadas de Automática: libro de actas. Castelló, 1-3 de septiembre de 2021 (pp. 485-491). DOI capítulo: https://doi.org/10.17979/spudc.9788497498043.485 DOI libro: https://doi.org/10.17979/spudc.9788497498043978-84-9749-804-3http://hdl.handle.net/2183/28367[Abstract] Inside a cell, protein, production and biosensor pathways can be genetically engineered within a dynamic regulation architecture that provides robustness to cell factories. Here we investigated how the selection of gene variants and their associated expression efficiency and kinetic parameters can lead to a wide diversity of dynamic responses in terms of protein or metabolite production. Results show that there is a trade-off between gene expression efficiency and pathway performance, and it can be eventually related to the evolutionary fingerprint of each gene variant. Therefore, the organism source of gene variants is a factor that needs to be considered in the design of dynamic regulation for genetic circuits.spaAtribución-NoComercial-CompartirIgual 4.0 Internacional https://creativecommons.org/licenses/by-nc-sa/4.0/deed.eshttp://creativecommons.org/licenses/by-nc-sa/3.0/es/Dynamic regulationBiosensorsCell factoriesBiomanufacturingconference outputopen accesshttps://doi.org/10.17979/spudc.9788497498043.485