Riveiro Naveira, Romina R.Valcárcel Ares, Marta NoaAlmonte-Becerril, MaylinVaamonde-García, CarlosLoureiro, JesúsHermida-Carballo, LauraLópez-Peláez, EduardoBlanco García, Francisco JLópez-Armada, María José2026-07-032026-07-032016-06-28Riveiro-Naveira RR, Valcárcel-Ares MN, Almonte-Becerril M, Vaamonde-García C, Loureiro J, Hermida-Carballo L, López-Peláez E, Blanco FJ, López-Armada MJ. Resveratrol lowers synovial hyperplasia, inflammatory markers and oxidative damage in an acute antigen-induced arthritis model. Rheumatology (Oxford). 2016 Oct;55(10):1889-900.1462-0332https://hdl.handle.net/2183/48748[Abstract] Objective: The present study aimed to determine the protective effects of dietary supplementation with resveratrol (RSV) in an acute antigen-induced arthritis (AIA) model. Methods: Rats were randomly divided into three groups: control, AIA and RSV-treated AIA group. RSV (12.5 mg/kg/day) was given orally for 8 weeks before induction of AIA and until the end of the experiment (48 h after intra-articular injection). The control and AIA animals were administered 100 μl of water. Results were evaluated by macroscopic observation, histopathology and immunohistochemistry for anti-PCNA, macrophages (CD68), T lymphocytes (CD3), monocyte chemoattractant protein-1 and 8-oxo-7,8-dihydro-2'-deoxyguanine (a marker of DNA damage). Cytokine-induced neutrophil chemoattractant-1 in serum and peroxidase activity in synovial tissue were measured using commercial kits. Results: At the end of the study, RSV significantly reduced knee swelling. Likewise, the histological score of synovial tissue also reduced significantly. The arthritis-protective effects were associated with a significant decrease in PCNA, CD68, CD3 and monocyte chemoattractant protein-1 staining, as well as a reduction in serum concentrations of cytokine-induced neutrophil chemoattractant-1. RSV treatment also decreased the level of the marker of DNA damage, 8-oxo-7,8-dihydro-2'-deoxyguanine. Accordingly, peroxidase activity in the synovial tissue was up-regulated. Conclusion: Dietary supplementation with RSV lowers the main pathological hallmarks of RA disease in an acute model of AIA. RSV may represent a promising strategy in controlling the severity of RA.engThis is a pre-copyedited, author-produced version of an article accepted for publication in Rheumatology following peer review. The version of record is available online on the OUP website.AntioxidantDietInflammationOxidative stressResveratrolRheumatoid arthritisSynovial tissue hyperplasiajournal articleopen access10.1093/RHEUMATOLOGY/KEW255