Seijo Bestilleiro, RocíoMartínez Señarís, DianaPereira Rodríguez, María JoséGaleiras, RitaGarcía Rodríguez, RaquelGarcía Rodríguez, María TeresaGonzález-Martín, CristinaSeoane-Pillado, TeresaBalboa-Barreiro, VanesaValdés Valiña, ValentínPértega-Díaz, Sonia2021-05-192021-05-192021-03-19Seijo Bestilleiro R, Martinez Señaris D, Pereira Rodríguez MJ, Galeiras Vázquez R, Bestilleiro RS, Señaris DM, Rodríguez MJP, Vázquez RG, Rodríguez RG, Rodriguez MTG, Martín CG, Pillado MTS, Barreiro VB, Valiña VV, Díaz SP. Nosocomial infection outbreak due to SARS-COV-2 in a hospital unit of particularly vulnerable patients. Int J Med Sci 2021; 18(10):2146-2154.1449-1907http://hdl.handle.net/2183/27949[Abstract] Objectives: To report a COVID-19 outbreak among workers and inpatients at a medical ward for especially vulnerable patients. Methods: Descriptive study of a nosocomial COVID-19 outbreak registered in March-April 2020 at medical ward of onco-hematological patients in an Spanish hospital. Confirmed cases were hospitalized patients, healthcare and non-healthcare workers who tested positive by PCR on a nasopharyngeal swab. Results: Twenty-two COVID-19 cases (12 workers and 10 inpatients) were laboratory-confirmed. Initial cases were a healthcare provider and a visitor who tested positive. The median patients age was 73 years (range 62-88). The main reason of admission was haematological in 8 patients and oncologic in 2. All patients followed an immunosuppressive treatment, 5/10 with high-flow oxygen nebulizations. Five patients presented a moderate/serious evolution, and 5 patients died. The mean workers age was 42.1±10.9. One healthworker required Intensive Care Unit admission, and all of them recovered completely. Conclusions: In the hospital setting, close patients surveillance for SARS-CoV-2 is essential, especially in immunosuppressed patients. Replacing nebulizations or high-flow oxygen therapies, when other equivalent options were available, to reduce dispersion, and controlling ventilation ducts, together with hygiene measures and an active follow-up on inpatients, visitors and workers appear to be important in preventing nosocomial outbreaks.engCreative Commons Attribution 4.0 International License (CC-BY 4.0)https://creativecommons.org/licenses/by/4.0/COVID-19Coronavirus InfectionsDisease outbreaksHealth personnelInfectious Disease Transmission-Professional-to-PatientInfectious Disesase Transmission-Patient-to-Professionaljournal articleopen access