Alonso-Marañón, LorenaSarandeses, Luis A.Martínez, M. MontserratPérez Sestelo, José2018-06-132018-06-132017Sequential In-catalyzed intramolecular hydroarylation and Pd-catalyzed cross-coupling reactions using bromopropargyl aryl ethers and amines. L. Alonso-Marañón, L. A. Sarandeses, M. M. Martínez and J. Pérez Sestelo, Org. Chem. Front., 2017, 4, 500–505.2052-41102052-4129http://hdl.handle.net/2183/20809[Abstract] A sequential one-pot indium-catalyzed intramolecular hydroarylation (IMHA) of bromopropargyl aryl ethers and amines, and palladium-catalyzed cross-coupling reaction using triorganoindium reagents (R3In) has been developed. In this transformation, the IMHA of 3-bromo-2-propynyl aryl ethers under indium(III) catalysis, proceeds regioselectively through a 6-endo dig pathway to afford 4-bromo-2Hchromenes. Subsequent palladium-catalyzed cross-coupling with R3In gives 4-substituted-2H-chromenes in one-pot. This sequential transformation was extended to 3-bromo-2-propynyl-N-tosylanilines to afford 4-substituted-1,2-dihydroquinolines. The dual-catalyzed procedure takes place efficiently with a variety of propargyl aryl ethers and amines and R3In (R = aryl, heteroaryl, alkyl or alkynyl), showing the efficiency of these organometallics and proving the compatibility of indium and palladium in catalysis.engAtribución 3.0 Españahttp://creativecommons.org/licenses/by-nc-sa/3.0/Lewis-acid catalysisHydroarylationIndium organometallicsCross-coupling reactionsjournal articleopen access