OXA-24 Carbapenemase Gene Flanked by XerC/XerD-Like Recombination Sites in Different Plasmids from Different Acinetobacter Species Isolated during a Nosocomial Outbreak

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UDC.coleccionInvestigación
UDC.departamentoBioloxía
UDC.departamentoFisioterapia, Medicina e Ciencias Biomédicas
UDC.endPage2727
UDC.institutoCentroINIBIC - Instituto de Investigacións Biomédicas de A Coruña
UDC.issue6 (June)
UDC.journalTitleAntimicrobial Agents and Chemotherapy
UDC.startPage2724
UDC.volume54 (2010)
dc.contributor.authorMerino Carballeira, María
dc.contributor.authorAcosta Barriga, Joshi
dc.contributor.authorPoza, Margarita
dc.contributor.authorSanz, Francisca
dc.contributor.authorBeceiro Casas, Alejandro
dc.contributor.authorChaves Sánchez, Fernando
dc.contributor.authorBou, Germán
dc.date.accessioned2026-03-10T21:23:39Z
dc.date.available2026-03-10T21:23:39Z
dc.date.issued2010-06-01
dc.description.abstract[Abstract] A clinical strain of Acinetobacter calcoaceticus resistant to carbapenems was isolated from a blood culture sample from an inpatient in a hospital in Madrid (Spain) during a large outbreak of infection (affecting more than 300 inpatients), caused by a multidrug-resistant Acinetobacter baumannii clone. The carbapenem resistance in both the A. calcoaceticus and A. baumannii clones was due to a blaOXA-24 gene harbored in different plasmids. The plasmids were fully sequenced, revealing the presence of site-specific recombination binding sites putatively involved in mobilization of the blaOXA-24 gene. Comparison of plasmids contained in the two strains revealed possible horizontal transmission of resistance genes between the Acinetobacter species.
dc.description.sponsorshipThis study was supported by the Spanish Network for Research on Infectious Diseases—REIPI (Instituto de Salud Carlos III, RD06/0008/0025 and RD006/0008/0011), Fondo de Investigaciones Sanitarias (PI061368, PI081368, and PS09/00687), and SERGAS (PS07/90) and by grants from Xunta de Galicia (07CSA050916PR). Margarita Poza and Alejandro Beceiro are in receipt of Isidro Parga Pondal and Angeles Alvariño grants, respectively (research contracts from Xunta de Galicia).
dc.description.sponsorshipXunta de Galicia; PS07/90
dc.description.sponsorshipXunta de Galicia; 07CSA050916PR
dc.identifier.citationMerino MAcosta JPoza M, Sanz F, Beceiro A, Chaves F, Bou G2010.OXA-24 Carbapenemase Gene Flanked by XerC/XerD-Like Recombination Sites in Different Plasmids from Different Acinetobacter Species Isolated during a Nosocomial Outbreak. Antimicrob Agents Chemother54:.https://doi.org/10.1128/aac.01674-09
dc.identifier.doi10.1128/aac.01674-09
dc.identifier.issn0066-4804
dc.identifier.issn1098-6596
dc.identifier.urihttps://hdl.handle.net/2183/47705
dc.language.isoeng
dc.publisherAmerican Society for Microbiology (ASM)
dc.relation.projectIDinfo:eu-repo/grantAgreement/MSC//RD06%2F0008%2F0025/ES/RED ESPAÑOLA DE INVESTIGACIÓN EN PATOLOGÍA INFECCIOSA (REIPI)/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MSC//RD06%2F0008%2F0011/ES/RED ESPAÑOLA DE INVESTIGACIÓN EN PATOLOGÍA INFECCIOSA (REIPI)/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MSC/Plan Nacional de I+D+i 2004-2007/PI061368/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN/Plan Nacional de I+D+i 2008-2011/PI081368/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN//PS09%2F00687/ES/MECANISMO DE ACCION DE LOS ANTIBIOTICOS EN ACINETOBACTER BAUMANNII Y ESTRES OXIDATIVO: APLICACION AL DIAGNOSTICO RAPIDO DE RESISTENCIAS A ANTIMICROBIANOS/
dc.relation.urihttps://doi.org/10.1128/aac.01674-09
dc.rights© 2010 American Society for Microbiology.
dc.rights.accessRightsopen access
dc.subjectAntibiotic Resistance
dc.subjectAntimicrobial Resistance
dc.subjectBacteriology
dc.subjectBeta-lactam Resistance
dc.subjectClinical Microbiology and Infectious Diseases
dc.subjectDrug Resistant Pathogens
dc.subjectEnzymatic Inactivation of Antibiotics
dc.subjectEvolution of Antibiotic Resistance
dc.subjectMicrobial Physiology and Genetics
dc.subjectPlasmids
dc.titleOXA-24 Carbapenemase Gene Flanked by XerC/XerD-Like Recombination Sites in Different Plasmids from Different Acinetobacter Species Isolated during a Nosocomial Outbreak
dc.typejournal article
dc.type.hasVersionVoR
dspace.entity.typePublication
relation.isAuthorOfPublicationa68d08dc-09ba-453e-8928-7c08e5b14a4b
relation.isAuthorOfPublication909e08d1-6ed1-4b99-9e9e-c64eb72e7dea
relation.isAuthorOfPublication.latestForDiscoverya68d08dc-09ba-453e-8928-7c08e5b14a4b

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