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https://hdl.handle.net/2183/48661 European mitochondrial haplogroups impact on liver fibrosis progression among HCV and HIV/HCV-coinfected patients from Northwest Spain
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Tabernilla, Andrés
Rego-Pérez, I.
Grandal, Marta
Pernas, Berta
Delgado, Manuel
Mariño, Ana
Álvarez, Hortensia
Mena, Álvaro
Rodríguez-Osorio, Iria
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Tabernilla A, Rego-Pérez I, Grandal M, Pernas B, Pértega S, Delgado M, Mariño A, Álvarez H, Mena A, Rodríguez-Osorio I, Pedreira JD, Blanco FJ, Poveda E. European mitochondrial haplogroups impact on liver fibrosis progression among HCV and HIV/HCV-coinfected patients from Northwest Spain. J Acquir Immune Defic Syndr. 2016 Oct 1;73(2):149-53.
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Abstract
[Abstract] The impact of mitochondrial DNA haplogroups on the outcome of liver fibrosis was evaluated in 362 hepatitis C virus infection (HCV)-monoinfected and HIV/HCV-coinfected patients (147 and 215, respectively) in clinical follow-up at 2 reference hospitals in the Northwest of Spain. The mitochondrial DNA haplogroup H was the most prevalent (50.3%) in this population. The cluster Others and V were recognized as risk factors for the development of liver fibrosis while haplogroup H and HCV genotype 4 confer a lower risk. This information might be useful for prioritization of HCV treatment, especially for F0-F1 patients for whom there is no urgency for treatment.
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This is a non-final version of an article published in final form in Journal of Acquired Immune Deficiency Syndromes.