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http://hdl.handle.net/2183/41165

Current positioning against severe infections due to klebsiella pneumoniae in hospitalized adults

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URI: http://hdl.handle.net/2183/41165
DOI: 10.3390/antibiotics11091160

Publication date

2022-08-27

Authors

Vidal-Cortés, Pablo
Martín-Loeches, Ignacio
Rodríguez, Alejandro
Cantón, Rafael
Díaz, Emili
De la Fuente, Carmen
Torre-Cisneros, Julián
Nuvials, Francisco Xavier
Salavert, Miguel

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Bibliographic citation

Vidal-Cortés P, Martin-Loeches I, Rodríguez A, Bou G, Cantón R, Diaz E, De la Fuente C, Torre-Cisneros J, Nuvials FX, Salavert M, Aguilar G, Nieto M, Ramírez P, Borges M, Soriano C, Ferrer R, Maseda E, Zaragoza R. Current positioning against severe infections due to klebsiella pneumoniae in hospitalized adults. Antibiotics (Basel). 2022 Aug 27;11(9):1160.

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Abstract

[Abstract] Infections due to Klebsiella pneumoniae have been increasing in intensive care units (ICUs) in the last decade. Such infections pose a serious problem, especially when antimicrobial resistance is present. We created a task force of experts, including specialists in intensive care medicine, anaesthesia, microbiology and infectious diseases, selected on the basis of their varied experience in the field of nosocomial infections, who conducted a comprehensive review of the recently published literature on the management of carbapenemase-producing Enterobacterales (CPE) infections in the intensive care setting from 2012 to 2022 to summarize the best available treatment. The group established priorities regarding management, based on both the risk of developing infections caused by K. pneumoniae and the risk of poor outcome. Moreover, we reviewed and updated the most important clinical entities and the new antibiotic treatments recently developed. After analysis of the priorities outlined, this group of experts established a series of recommendations and designed a management algorithm.

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Review

Keywords

ICU KPC Klebsiella pneumoniae VAP Carbapenemase-producing Enterobacterales (CPE) Cefiderocol Ceftazidime avibactam Imipenem relebactam Meropenem vaborbactam Nosocomial pneumonia

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https://doi.org/10.3390/antibiotics11091160

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Creative Commons Attribution 4.0 International License (CC-BY 4.0)

Except where otherwise noted, this item's license is described as Creative Commons Attribution 4.0 International License (CC-BY 4.0)