Circulating levels of GDF15, MMP7 and miR-200c as a poor prognostic signature in gastric cancer

Blanco, Moisés; Tarrío, Nuria; Reboredo, Margarita; Haz, Mar; García, Jorge; Quindós-Varela, María; Figueroa, Angélica; Antón-Aparicio, Luis M.; Calvo, Lourdes; Valladares-Ayerbes, Manuel

Use this link to cite:

http://hdl.handle.net/2183/21886

Circulating levels of GDF15, MMP7 and miR-200c as a poor prognostic signature in gastric cancer

Files

Blanco-Calvo_Circulating.pdf (534.74 KB)

Identifiers

URI: http://hdl.handle.net/2183/21886

Publication date

2014-06-20

Authors

Blanco, Moisés

Tarrío, Nuria

Reboredo, Margarita

Haz, Mar

García, Jorge

Quindós-Varela, María

Figueroa, Angélica

Antón-Aparicio, Luis M.

Calvo, Lourdes

Valladares-Ayerbes, Manuel

Bibliographic citation

Blanco-Calvo M, Tarrío N, Reboredo M, et al. Circulating levels of GDF15, MMP7 and miR-200c as a poor prognostic signature in gastric cancer. Future Oncol. 2014; 10(7): 1187-1202

Abstract

[Abstract] Aim: To analyze GDF15 and MMP7 serum levels as diagnostic biomarkers in gastric cancer (GC) patients. The prognostic value of GDF15 and MMP7 serum levels in combination with miR-200c blood expression was also analyzed. Patients & methods: Fifty-two GC and 23 control samples were included. Results: GDF15 and MMP7 proved to be powerful tools for GC diagnosis. Increased levels of GDF15 and MMP7 were associated with shorter progression-free survival and overall survival in univariate analysis. In multivariate analysis, the combination of high levels of GDF15, MMP7 and miR-200c was an independent predictor for death (p = 0.033). Conclusion: GDF15 and MMP7 serum levels have diagnostic value for GC. The combination marker formed by GDF15, MMP7 and miR-200c is indicative of adverse evolution in GC patients.