Solid-Phase Zincke Reaction for the Synthesis of Peptide-4,4′-bipyridinium Conjugates

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UDC.coleccionInvestigaciónes_ES
UDC.departamentoQuímicaes_ES
UDC.endPage543es_ES
UDC.grupoInvQuímica Molecular e de Materiais (QUIMOLMAT)es_ES
UDC.issue4es_ES
UDC.journalTitleSynthesises_ES
UDC.startPage537es_ES
UDC.volume52es_ES
dc.contributor.authorCortón, Pablo
dc.contributor.authorNovo, Paula
dc.contributor.authorLópez Sobrado, Vanesa
dc.contributor.authorGarcía, Marcos D.
dc.contributor.authorPeinador, Carlos
dc.contributor.authorPazos, Elena
dc.date.accessioned2024-10-08T09:23:57Z
dc.date.available2024-10-08T09:23:57Z
dc.date.issued2020-02
dc.descriptionAuthor accepted manuscriptes_ES
dc.description.abstract[Abstract] We present herein the development of a new synthetic strategy for the conjugation of 4,4′-bipyridinium derivatives into peptide scaffolds. The methodology, based on the development of a solid-phase version of the Zincke reaction between activated pyridinium salts and amines, is able to produce the desired conjugates in a straightforward fashion, with the bipyridinium units attached at the N-terminus of peptides or at Lys side chains of N-terminal acetylated peptides.es_ES
dc.description.sponsorshipThis work has received financial support from the Ministerio de Economía y Competitividad and Fondo Europeo de Desarrollo Regional (FEDER) (CTQ2016-75629-P), Agencia Estatal de Investigación and FEDER (CTQ2017-89166-R), and the Consellería de Educación, Universidade e Formación Profesional, Xunta de Galicia (ED431C 2018/39)es_ES
dc.description.sponsorshipXunta de Galicia; ED431C 2018/39es_ES
dc.identifier.citationCortón, P. N., Paula; López-Sobrado, Vanesa; García, Marcos D. ;. Peinador, Carlos; Pazos, Elena Synthesis 2020, 52, 537.es_ES
dc.identifier.doi10.1055/s-0039-1690016
dc.identifier.issn1437-210X
dc.identifier.issn0039-7881
dc.identifier.urihttp://hdl.handle.net/2183/39488
dc.language.isoenges_ES
dc.publisherThiemees_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2016-75629-P/ESes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2017-89166-R/ES/HERRAMIENTAS PEPTIDICAS PARA APLICACIONES BIOLOGICAS: SENSORES INTELIGENTES PARA ESTUDIAR NITRACION DE PROTEINAS Y NANOMATERIALES CON FUNCIONALIDADES MODULABLESes_ES
dc.relation.urihttps://doi.org/10.1055/s-0039-1690016es_ES
dc.rights.accessRightsopen accesses_ES
dc.subjectPeptide-based conjugateses_ES
dc.subjectViologenses_ES
dc.subjectZincke reactiones_ES
dc.subjectSolid Phase Peptide Synthesis (SPPS)es_ES
dc.subjectSynthetic methodologyes_ES
dc.titleSolid-Phase Zincke Reaction for the Synthesis of Peptide-4,4′-bipyridinium Conjugateses_ES
dc.typejournal articlees_ES
dspace.entity.typePublication
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relation.isAuthorOfPublication86a2d4e7-c65e-4cbb-ad78-02434b0eca6d
relation.isAuthorOfPublicationdf653ec8-e85e-4f0c-9ffb-4b81d43fc20c
relation.isAuthorOfPublication2937ed3e-6088-4530-ba68-f72739264fd1
relation.isAuthorOfPublication.latestForDiscovery0b521d05-55e2-4404-a286-df73815a4388

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