Connection of Isolated Stereoclusters by Combining 13C-RCSA, RDC, and J-Based Configurational Analyses and Structural Revision of a Tetraprenyltoluquinol Chromane Meroterpenoid from Sargassum muticum

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UDC.coleccionInvestigaciónes_ES
UDC.departamentoQuímicaes_ES
UDC.grupoInvQuímica Molecular e de Materiais (QUIMOLMAT)es_ES
UDC.issue7es_ES
UDC.journalTitleMarine drugses_ES
UDC.startPage462es_ES
UDC.volume20es_ES
dc.contributor.authorFuentes-Monteverde, Juan Carlos
dc.contributor.authorNath, Nilamoni
dc.contributor.authorForero, Abel M.
dc.contributor.authorBalboa, Elena M.
dc.contributor.authorNavarro-Vázquez, Armando
dc.contributor.authorGriesinger, Christian
dc.contributor.authorJiménez, Carlos
dc.contributor.authorRodríguez, Jaime
dc.date.accessioned2022-10-11T19:10:20Z
dc.date.available2022-10-11T19:10:20Z
dc.date.issued2022
dc.descriptionThis article belongs to the Special Issue Marine Drugs Research in Spaines_ES
dc.description.abstract[Abstract] The seaweed Sargassum muticum, collected on the southern coast of Galicia, yielded a tetraprenyltoluquinol chromane meroditerpene compound known as 1b, whose structure is revised. The relative configuration of 1b was determined by J-based configurational methodology combined with an iJ/DP4 statistical analysis and further confirmed by measuring two anisotropic properties: carbon residual chemical shift anisotropies (13C-RCSAs) and one-bond 1H-13C residual dipolar couplings (1DCH-RDCs). The absolute configuration of 1b was deduced by ECD/OR/TD-DFT methods and established as 3R,7S,11R.es_ES
dc.description.sponsorshipThis work was funded by grants RTI2018-093634-B-C22 from the State Agency for Research (AEI) of Spain, both co-funded by the European Regional Development Fund (ERDF), BLUEBIOLAB (0474_BLUEBIOLAB_1_E), Programme INTERREG V A of Spain–Portugal (POCTEP) and GRC2018/039 and Agrupación Estratégica CICA-INIBIC ED431E 2018/03 from Xunta de Galicia. This work was also supported by the Max Planck Society and grew out of a collaboration in the context of the Forschergruppe (FOR 934), continued now by the DFG (Gr1211/19–1 and Re1007/9–1)/CAPES 418729698 Project. N.N. gratefully acknowledges the financial support by SERB, New Delhi for ECR Grant with File No.: ECR/2017/001811es_ES
dc.description.sponsorshipXunta de Galicia; ED431E 2018/03es_ES
dc.description.sponsorshipGerman Research Foundation; Gr1211/19–1es_ES
dc.description.sponsorshipGerman Research Foundation; Re1007/9–1es_ES
dc.description.sponsorshipBrasil. Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); 418729698es_ES
dc.description.sponsorshipRepública de la India. Science and Engineering Research Board; ECR/2017/001811es_ES
dc.description.sponsorshipXunta de Galicia; GRC2018/039es_ES
dc.identifier.citationFuentes-Monteverde, J.C.C.; Nath, N.; Forero, A.M.; Balboa, E.M.; Navarro-Vázquez, A.; Griesinger, C.; Jiménez, C.; Rodríguez, J. Connection of Isolated Stereoclusters by Combining 13C-RCSA, RDC, and J-Based Configurational Analyses and Structural Revision of a Tetraprenyltoluquinol Chromane Meroterpenoid from Sargassum muticum. Mar. Drugs 2022, 20, 462. https://doi.org/10.3390/md20070462es_ES
dc.identifier.doi10.3390/md20070462
dc.identifier.issn1660-3397
dc.identifier.urihttp://hdl.handle.net/2183/31799
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-093634-B-C22/ES/FACTORES DE VIRULENCIA BACTERIANOS COMO DIANAS TERAPEUTICAS EN PECES: CARACTERIZACION DE SIDEROFOROS Y DESARROLLO DE NUEVOS TRATAMIENTOS CONTRA FORUNCULOSIS Y TENACIBACULOSIS/es_ES
dc.relation.urihttps://doi.org/10.3390/md20070462es_ES
dc.rightsAtribución 4.0 Internacional (CC BY 4.0)es_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectSargassum muticumes_ES
dc.subjectMeroditerpenees_ES
dc.subjectCoupling constantses_ES
dc.subjectJ-DP4es_ES
dc.subject13C-RCSAes_ES
dc.subjectRDCes_ES
dc.subjectECD/ORes_ES
dc.titleConnection of Isolated Stereoclusters by Combining 13C-RCSA, RDC, and J-Based Configurational Analyses and Structural Revision of a Tetraprenyltoluquinol Chromane Meroterpenoid from Sargassum muticumes_ES
dc.typejournal articlees_ES
dspace.entity.typePublication
relation.isAuthorOfPublication5b28838e-d3db-4925-9246-cb19f8f8da9d
relation.isAuthorOfPublication4f74f579-b8ea-46ec-a9c1-5783a449e587
relation.isAuthorOfPublication.latestForDiscovery5b28838e-d3db-4925-9246-cb19f8f8da9d

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