Intrinsic and Selective Activity of Functionalized Carbon Nanotube/Nanocellulose Platforms Against Colon Cancer Cells

González-Domínguez, José Miguel; Grasa, Laura; Frontiñán, Javier; Abás, Elisa; Domínguez-Alfaro, Antonio; Mesonero, J. E.; Criado, Alejandro; Ansón-Casaos, Alejandro

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http://hdl.handle.net/2183/31531

Intrinsic and Selective Activity of Functionalized Carbon Nanotube/Nanocellulose Platforms Against Colon Cancer Cells

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Criado_Alejandro_2022_Intrinsic_selective_activity_functionalized_carbon_nanotubenanocellulose_platforms_against_colon_cancer_cells.pdf (13.78 MB)

Identifiers

URI: http://hdl.handle.net/2183/31531

DOI: 10.1016/j.colsurfb.2022.112363

Publication date

2022-01-25

Authors

González-Domínguez, José Miguel

Grasa, Laura

Frontiñán, Javier

Abás, Elisa

Domínguez-Alfaro, Antonio

Mesonero, J. E.

Criado, Alejandro

Ansón-Casaos, Alejandro

Bibliographic citation

J.M. González-Domínguez, L. Grasa, J. Frontiñán-Rubio, E. Abás, A. Domínguez-Alfaro, J.E. Mesonero, A. Criado, A. Ansón-Casaos, Intrinsic and selective activity of functionalized carbon nanotube/nanocellulose platforms against colon cancer cells, Colloids and Surfaces B: Biointerfaces. 212 (2022). https://doi.org/10.1016/j.colsurfb.2022.112363

Abstract

[Abstract] Given their large surface area and versatile chemical reactivity, single-walled carbon nanotubes (SWCNTs) are regarded as the basis of new pharmacological complexes. In this study, SWCNTs are chemically functionalized with fluorescein, folic acid, and capecitabine, a drug that is commonly used against colorectal cancer. These functionalized SWCNTs are dispersed in water by taking advantage of their synergistic interaction with type-II nanocrystalline cellulose (II-NCC), and the resulting colloidal system is tested in vitro on both normal (differentiated) and cancerous (proliferative) human colon cells (Caco-2). The functionalized SWCNT/II-NCC hybrids show a higher activity than the reference (capecitabine) against the Caco-2 cancer cell line. However, this effect appears to be intrinsically associated with the SWCNT/II-NCC complex, particularly boosted by fluorescein, as the presence of capecitabine is not required. In addition, confocal microscopy fluorescence imaging using cell cultures highlights the enormous potential of this nanohybrid platform for colon cancer theranostics.