Light-Emitting Probes for Labeling Peptides

Boaro, Andreia; Ageitos, Lucía; Torres, Marcelo; Bartoloni, Fernando Heering; De la Fuente, César

Use this link to cite:

http://hdl.handle.net/2183/27858

Light-Emitting Probes for Labeling Peptides

Files

Ageitos_Lucia_2020_Light-emitting_probes_labeling_peptides.pdf (1.74 MB)

Identifiers

URI: http://hdl.handle.net/2183/27858

Publication date

2020-11-25

Authors

Boaro, Andreia

Ageitos, Lucía

Torres, Marcelo

Bartoloni, Fernando Heering

De la Fuente, César

Bibliographic citation

Boaro, A., Ageitos, L., Torres, M., Bartoloni, F.H., and de la Fuente-Nunez, C. (2020). Light-Emitting Probes for Labeling Peptides. Cell Reports Phys. Sci. 1, 100257

Abstract

[Abstract] Peptides are versatile biopolymers composed of 2–100 amino acid residues that present a wide range of biological functions and constitute potential therapies for numerous diseases, partly due to their ability to penetrate cell membranes. However, their mechanisms of action have not been fully elucidated due to the lack of appropriate tools. Existing light-emitting probes are limited by their cytotoxicity and large size, which can alter peptide structure and function. Here, we describe the available fluorescent, bioluminescent, and chemiluminescent probes for labeling peptides, with a focus on minimalistic options.