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http://hdl.handle.net/2183/30405 A new index to predict quality of anticoagulation control in patients on vitamin K antagonists: the DAFNE score
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Barrios, Vivencio
Escobar, Carlos
Prieto-Valiente, Luis
Polo García, José
Anguita, Manuel
Lip, Gregory Y.H.
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Barrios V, Escobar C, Prieto L, Polo J, Muñiz J, Anguita M, H Lip GY. A new index to predict quality of anticoagulation control in patients on vitamin K antagonists: the DAFNE score. Future Cardiol. 2021 Jul;17(4):685-692.
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Abstract
[Abstract] Aim: To derive a new clinical score to improve the prediction of those at risk of poor International Normalized Ratio control among patients with atrial fibrillation taking vitamin K antagonists. Materials & methods: The score was calculated using PAULA database and validated in the FANTASIIA population. Results: The DAFNE score (cardiovascular Disease, concomitant treatment with Amiodarone, Food/dietary transgression and taking ≥7 pills daily, fEemale sex) score was related to a higher probability of poor International Normalized Ratio control. C-indexes were 0.611 and 0.576 (De Long test, p = 0.007) for the DAFNE and SAMe-TT2R2 scores, respectively. Conclusion: The DAFNE score is a new clinical score which may potentially help determine those patients with atrial fibrillation who are at high risk of poor anticoagulation control with vitamin K antagonists.