Mitochondrial DNA haplogroup H as a risk factor for idiopathic dilated cardiomyopathy in Spanish population

Fernández Caggiano, Mariana; Barallobre-Barreiro, Javier; Rego-Pérez, I.; Crespo-Leiro, María Generosa; Paniagua-Martín, María J.; Grille-Cancela, Zulaika; Blanco García, Francisco J; Doménech, Nieves

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http://hdl.handle.net/2183/19475

Mitochondrial DNA haplogroup H as a risk factor for idiopathic dilated cardiomyopathy in Spanish population

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Identifiers

URI: http://hdl.handle.net/2183/19475

Publication date

2013-03-23

Authors

Fernández Caggiano, Mariana

Barallobre-Barreiro, Javier

Rego-Pérez, I.

Crespo-Leiro, María Generosa

Paniagua-Martín, María J.

Grille-Cancela, Zulaika

Blanco García, Francisco J

Doménech, Nieves

Bibliographic citation

Fernández-Caggiano M, Barallobre-Barreiro J, Rego-Pérez I, et al. Mitochondrial DNA haplogroup H as a risk factor for idiopathic dilated cardiomyopathy in spanish population. Mitochondrion. 2013;13(4):263-268

Abstract

[Abstract] Idiopathic dilated cardiomyopathy (IDC) is a structural heart disease with strong genetic background. The different single nucleotide polymorphisms (SNPs) that constitute mitochondrial haplogroups could play an important role in IDC progression. The aim of this study was to test frequencies of mitochondrial haplogroups in healthy controls (n = 422) and IDC patients (n = 304) of a Caucasian Spanish population. To achieve this, ten major European haplogroups were identified. Frequencies and Odds Ratios for the association between IDC and haplogroups were calculated in both groups. We found that compared to healthy controls, the prevalence of haplogroup H was significantly higher in IDC patients (40.0% vs 50.7%, p-value = 0.040).