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http://hdl.handle.net/2183/29752 Mesenchymal stem cell functionalization for enhanced therapeutic applications
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Kouroupis D, Sanjurjo-Rodríguez C, Jones E, Correa D. Mesenchymal stem cell functionalization for enhanced therapeutic applications. Tissue Eng Part B Rev. 2019;25(1):55-77
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Abstract
[Abstract] Culture expansion of MSCs has detrimental effects on various cell characteristics and attributes (e.g., phenotypic changes and senescence), which, in addition to inherent interdonor variability, negatively impact the standardization and reproducibility of their therapeutic potential. The identification of innate distinct functional MSC subpopulations, as well as the description of ex vivo protocols aimed at maintaining phenotypes and enhancing specific functions have the potential to overcome these limitations. The incorporation of those approaches into cell-based therapy would significantly impact the field, as more reproducible clinical outcomes may be achieved.
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This is the original submission version (pre-peer review) of the article which has now been formally published in final form at Tissue Engineering Part B. This original submission version of the article may be used for non-commercial purposes in accordance with the Mary Ann Liebert, Inc., publishers’ Self-Archiving Terms and Conditions.